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Details

Stereochemistry RACEMIC
Molecular Formula C12H16N2
Molecular Weight 188.2688
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FENPROPOREX

SMILES

CC(CC1=CC=CC=C1)NCCC#N

InChI

InChIKey=IQUFSXIQAFPIMR-UHFFFAOYSA-N
InChI=1S/C12H16N2/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,9-10H2,1H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://en.pharmacodia.com/web/drug/1_10952.html | http://www.ndrugs.com/?s=fenproporex%20hydrochloride&t=dosage | http://www.doctoralia.com.mx/medicamento/esbelcaps-53723

Fenproporex is a central and indirect-acting sympathomimetic. It was developed as an anorectic drug. Their anorectic effects are believed to be a result of adrenergic activation. Fenproporex has never been approved by the US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. There is a paucity of randomized, placebo-controlled trials on Fenproporex. These studies suggest that Fenproporex is modestly effective in promoting weight loss. Data from these studies are insufficient to determine the risk-benefit profile of Fenproporex. Abuse potential and amphetamine-like adverse effects are causes for concern. Adverse effect most frequently reported are: insomnia, anxiety, depression, irritability, dry mouth.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Esbelcaps

Approved Use

Anorexigenic. Assist in the treatment of obesity. An adjuvant to the establishment of a low-calorie diet.
PubMed

PubMed

TitleDatePubMed
Amphetamine poisoning in a dog: case report, literature review and veterinary medical perspectives.
2003 Dec
Diabesity: are weight loss medications effective?
2005
[Prescription, dispensing, and regulation of psychoactive anorexigenic drugs in Belo Horizonte, Minas Gerais, Brazil].
2008 Aug
Imported fenproporex-based diet pills from Brazil: a report of two cases.
2009 Mar
Patents

Sample Use Guides

The initial dose is 10 mg/day. The dose might be increased up to 15 mg/day.
Route of Administration: Oral
In presence of 3 uM inhibitor quinidine and 50 uM Fenproporex the metabolite formation of the S(+)-enantiomer was significantly (P value 0.0145) inhibited.
Name Type Language
FENPROPOREX
INN   MI   WHO-DD  
INN  
Official Name English
(±)-3-((.ALPHA.-METHYLPHENETHYL)AMINO)PROPIONITRILE
Systematic Name English
FENOREX
Brand Name English
fenproporex [INN]
Common Name English
Fenproporex [WHO-DD]
Common Name English
FEMPROPOREX
Common Name English
FENPROPOREX [MI]
Common Name English
J268.797F
Code English
Classification Tree Code System Code
DEA NO. 1575
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
NCI_THESAURUS C29728
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
Code System Code Type Description
EVMPD
SUB07592MIG
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
CAS
16397-28-7
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
INN
2176
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
ECHA (EC/EINECS)
239-772-0
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
ALTERNATIVE
PUBCHEM
61810
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
NCI_THESAURUS
C65669
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
DRUG BANK
DB01550
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
ChEMBL
CHEMBL2105566
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
MERCK INDEX
m5292
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY Merck Index
DRUG CENTRAL
1161
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
CAS
15686-61-0
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
SUPERSEDED
FDA UNII
W0194S5FOA
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
EPA CompTox
DTXSID0043921
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
RXCUI
24867
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY RxNorm
SMS_ID
100000081486
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
WIKIPEDIA
FENPROPOREX
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
MESH
C026013
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY
ECHA (EC/EINECS)
240-444-4
Created by admin on Sat Dec 16 16:47:14 UTC 2023 , Edited by admin on Sat Dec 16 16:47:14 UTC 2023
PRIMARY