Details
Stereochemistry | ACHIRAL |
Molecular Formula | C28H40N4S |
Molecular Weight | 464.709 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C1=CC(C(C)C)=C(C2=CSC(=N2)N(CCN(C)C)CC3=CC=CN=C3)C(=C1)C(C)C
InChI
InChIKey=VVBFISAUNSXQGZ-UHFFFAOYSA-N
InChI=1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: P25105 Gene ID: 5724.0 Gene Symbol: PTAFR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1656029 |
57.0 pM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Role of tachykinins in castor oil diarrhoea in rats. | 1997 Jun |
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Platelet-leukocyte cross talk in whole blood. | 2000 Dec |
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Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. | 2004 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10543285
In acute asthma study, foropafant was administered orally at 20 mg dosage
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1656029
Foropafant displayed marked in vitro inhibition of PAF-induced oxidative burst in guinea pig macrophages (IC50 = 32 nM). Foropafant potently inhibited PAF-induced aggregation of rabbit and human platelets in vitro (IC50 = 0.10 and 0.50 nM, respectively).
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C1327
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C65756
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119368
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CHEMBL1628662
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100000080455
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136468-36-5
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VWJ2QVH41J
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SUB07789MIG
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)