IPROHEPTINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H25N.ClH
Molecular Weight	207.784
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)CCCC(C)NC(C)C

InChI

InChIKey=QYEORIIWGAAORG-UHFFFAOYSA-N

InChI=1S/C11H25N.ClH/c1-9(2)7-6-8-11(5)12-10(3)4;/h9-12H,6-8H2,1-5H3;1H

HIDE SMILES / InChI

Description
Sources: http://iccb.med.harvard.edu/files/iccb/files/msdisc1_knownbioactivelibraries_activities_website_09092015.pdf | http://www.google.ch/patents/WO2005094832A1

Iproheptine (Metron, Susat) is a vasoconstrictor, antihistamine, nasal decongestant marketed in Japan.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 316 Target ID: CHEMBL231 Sources: http://www.google.ch/patents/WO2005094832A1 \| http://www.chemicalland21.com/info/ANTIHISTAMINES.htm	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Nasal congestion 27 Sources: http://iccb.med.harvard.edu/files/iccb/files/msdisc1_knownbioactivelibraries_activities_website_09092015.pdf http://www.google.ch/patents/WO2005094832A1	Primary		Approved 8583	METRON Approved Use Vasoconstrictor, antihistamine, nasal decongestant

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1087			inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP19A1 429	P-gp 2052

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP19A1 430	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19917#section=Biological-Test-Results Page: 34.0	no
CYP3A4 2633	inducer 1966 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19917#section=Biological-Test-Results Page: 34.0	no

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 2052	substrate 4014 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19917#section=Biological-Test-Results Page: 36 \| 38	no

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/19917#section=Biological-Test-Results Page: 19.0

Patents

Sample Use Guides

In Vivo Use Guide

Maximum daily dose - 150mg

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

IPROHEPTINE HYDROCHLORIDE

Common Name

English

IPROHEPTINE HYDROCHLORIDE [JAN]

Preferred Name

English

Iproheptine hydrochloride [WHO-DD]

Common Name

English

N-ISOPROPYL-6-METHYL-2-HEPTYLAMINE HYDROCHLORIDE

Systematic Name

English

6-METHYL-N-(1-METHYLETHYL)-2-HEPTANAMINE HYDROCHLORIDE

Systematic Name

English

2-HEPTANAMINE, 6-METHYL-N-(1-METHYLETHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578