Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H2O4.Ca |
| Molecular Weight | 154.134 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Ca++].[O-]C(=O)\C=C\C([O-])=O
InChI
InChIKey=HDRTWMBOUSPQON-TYYBGVCCSA-L
InChI=1S/C4H4O4.Ca/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;
Calcium Fumarate is a calcium salt of fumaric acid, it can be used as a food supplement. Calcium Fumarate may be used to treat conditions caused by low Calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough Calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone). Calcium Fumarate is
classified by the FDA as a dietary and nutritional
additive (21CFR§172.350) and has been used for many
years.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Calcium Fumarate Approved UseIndication: For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Dietary inclusion of diallyl disulfide, yucca powder, calcium fumarate, an extruded linseed product, or medium-chain fatty acids does not affect methane production in lactating dairy cows. | 2011 Jun |
|
| Effects of a combination of feed additives on methane production, diet digestibility, and animal performance in lactating dairy cows. | 2011 Mar |
|
| Mechanical Properties of a Calcium Dietary Supplement, Calcium Fumarate Trihydrate. | 2015 Dec 7 |
Patents
Sample Use Guides
According to the treatment
schedule, after a 12 hours overnight fast, each subject was
given tablets containing 675mg calcium in total either in
the form of calcium gluconate or calcium fumarate orally
with a glass of water. Standard breakfast was served after
the 4th hour.
Route of Administration:
Oral
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CFR |
21 CFR 172.350
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243-376-3
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100000181305
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19855-56-2
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CALCIUM FUMARATE
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7718-51-6
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SUB194891
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VD906S8V0I
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6433512
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DTXSID001337577
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C480820
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
