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Details

Stereochemistry ACHIRAL
Molecular Formula C4H2O4.Ca
Molecular Weight 154.134
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM FUMARATE

SMILES

[Ca++].[O-]C(=O)\C=C\C([O-])=O

InChI

InChIKey=HDRTWMBOUSPQON-TYYBGVCCSA-L
InChI=1S/C4H4O4.Ca/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;

HIDE SMILES / InChI
Calcium Fumarate is a calcium salt of fumaric acid, it can be used as a food supplement. Calcium Fumarate may be used to treat conditions caused by low Calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough Calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone). Calcium Fumarate is classified by the FDA as a dietary and nutritional additive (21CFR§172.350) and has been used for many years.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Calcium Fumarate

Approved Use

Indication: For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.
PubMed

PubMed

TitleDatePubMed
Dietary inclusion of diallyl disulfide, yucca powder, calcium fumarate, an extruded linseed product, or medium-chain fatty acids does not affect methane production in lactating dairy cows.
2011 Jun
Effects of a combination of feed additives on methane production, diet digestibility, and animal performance in lactating dairy cows.
2011 Mar
Mechanical Properties of a Calcium Dietary Supplement, Calcium Fumarate Trihydrate.
2015 Dec 7
Patents

Patents

Sample Use Guides

According to the treatment schedule, after a 12 hours overnight fast, each subject was given tablets containing 675mg calcium in total either in the form of calcium gluconate or calcium fumarate orally with a glass of water. Standard breakfast was served after the 4th hour.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
CALCIUM FUMARATE
Systematic Name English
CALCIUM (E)-BUT-2-ENEDIOATE
Systematic Name English
E367
Common Name English
FULAXAN
Common Name English
2-BUTENEDIOIC ACID (2E)-, CALCIUM SALT
Common Name English
2-BUTENEDIOIC ACID (E)-, CALCIUM SALT
Systematic Name English
Calcium fumarate [WHO-DD]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 172.350
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
243-376-3
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
PRIMARY
SMS_ID
100000181305
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
PRIMARY
CAS
19855-56-2
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
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WIKIPEDIA
CALCIUM FUMARATE
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
PRIMARY
CAS
7718-51-6
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
NON-SPECIFIC STOICHIOMETRY
EVMPD
SUB194891
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
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FDA UNII
VD906S8V0I
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
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PUBCHEM
6433512
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
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EPA CompTox
DTXSID001337577
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
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MESH
C480820
Created by admin on Fri Dec 15 15:24:26 GMT 2023 , Edited by admin on Fri Dec 15 15:24:26 GMT 2023
PRIMARY