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Details

Stereochemistry RACEMIC
Molecular Formula C19H18N2O4
Molecular Weight 338.3572
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIMOXATONE

SMILES

COCC1CN(C(=O)O1)C2=CC=C(OCC3=CC=CC(=C3)C#N)C=C2

InChI

InChIKey=MVVJINIUPYKZHR-UHFFFAOYSA-N
InChI=1S/C19H18N2O4/c1-23-13-18-11-21(19(22)25-18)16-5-7-17(8-6-16)24-12-15-4-2-3-14(9-15)10-20/h2-9,18H,11-13H2,1H3

HIDE SMILES / InChI
Cimoxatone is a fully reversible inhibitor selective for the A form of monoamine oxidase. Oral administration of Cimoxatone increased brain noradrenaline, dopamine, and serotonin and decreased DOPAC , 5-HIAA, and 3-methoxy-4-hydroxyphenylethylene glycol sulfate.

Approval Year

PubMed

PubMed

TitleDatePubMed
Some biochemical aspects of the potential benefit of associating MD780515 with tricyclic antidepressants.
1981 Oct
Neuropharmacological profile of MD 780515, a new reversible inhibitor of type A monoamine oxidase.
1982 Oct
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
2004 Sep
Patents

Patents

Sample Use Guides

40 mg as a single dose
Route of Administration: Oral
Name Type Language
CIMOXATONE
INN   MART.  
INN  
Official Name English
CIMOXATONE [MART.]
Common Name English
.ALPHA.-(P-(5-(METHOXYMETHYL)-2-OXO-3-OXAZOLIDINYL)PHENOXY)-M-TOLUNITRILE
Common Name English
cimoxatone [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C667
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
Code System Code Type Description
INN
5004
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
PRIMARY
CAS
73815-11-9
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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WIKIPEDIA
Cimoxatone
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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ChEMBL
CHEMBL2104092
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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MESH
C026234
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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NCI_THESAURUS
C90879
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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ECHA (EC/EINECS)
277-613-7
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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PUBCHEM
52542
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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SMS_ID
100000081057
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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EPA CompTox
DTXSID50868273
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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FDA UNII
V6FT1QJ7VL
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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EVMPD
SUB06281MIG
Created by admin on Fri Dec 15 15:16:45 GMT 2023 , Edited by admin on Fri Dec 15 15:16:45 GMT 2023
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