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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H23N3O6S
Molecular Weight 457.5
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETAVOPIVAT

SMILES

OC[C@@H](C(=O)N1CC2=C(C1)CN(C2)S(=O)(=O)C3=CN=C4OCCOC4=C3)C5=CC=CC=C5

InChI

InChIKey=KZFFYEPYCVDOGE-LJQANCHMSA-N
InChI=1S/C22H23N3O6S/c26-14-19(15-4-2-1-3-5-15)22(27)24-10-16-12-25(13-17(16)11-24)32(28,29)18-8-20-21(23-9-18)31-7-6-30-20/h1-5,8-9,19,26H,6-7,10-14H2/t19-/m1/s1

HIDE SMILES / InChI

Approval Year

Unknown
149,124

Cmax

ValueDoseCo-administeredAnalytePopulation
786 ng/mL
400 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
2652 ng/mL
700 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
2663 ng/mL
1000 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
2847 ng × h/mL
400 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
7254 ng × h/mL
700 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
9618 ng × h/mL
1000 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
12.9 h
400 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
13.8 h
700 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
10.6 h
1000 mg single, oral
 ETAVOPIVAT plasma
Homo sapiens
ACTIVE MOIETY
Structure of ETAVOPIVAT
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