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Details

Stereochemistry RACEMIC
Molecular Formula C27H34N4O10
Molecular Weight 574.5797
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RAZINODIL

SMILES

COC1=CC(=CC(OC)=C1OC)C(=O)OC(CN2CCOCC2)CN3N=NC4=C(OC)C(OC)=C(OC)C=C4C3=O

InChI

InChIKey=KUUKBTYSAHIXTN-UHFFFAOYSA-N
InChI=1S/C27H34N4O10/c1-34-19-11-16(12-20(35-2)23(19)37-4)27(33)41-17(14-30-7-9-40-10-8-30)15-31-26(32)18-13-21(36-3)24(38-5)25(39-6)22(18)28-29-31/h11-13,17H,7-10,14-15H2,1-6H3

HIDE SMILES / InChI

Description

Razinodil was developed as a coronary vasodilator, a drug that reduces blood pressure by dilating blood vessels. It was tested for its potential as a drug in ischemic myocardial diseases. In a canine heart-lung laboratory model, it increased coronary blood flow without increasing oxygen consumption. Only slight negative chronotropic (heart rate) and inotropic (cardiac contraction) effects were reported. Razinodil also improved the survival rate of miniature pigs after an induced heart attack.

Approval Year