RAZINODIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C27H34N4O10
Molecular Weight	574.5797
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(=CC(OC)=C1OC)C(=O)OC(CN2CCOCC2)CN3N=NC4=C(OC)C(OC)=C(OC)C=C4C3=O

InChI

InChIKey=KUUKBTYSAHIXTN-UHFFFAOYSA-N

InChI=1S/C27H34N4O10/c1-34-19-11-16(12-20(35-2)23(19)37-4)27(33)41-17(14-30-7-9-40-10-8-30)15-31-26(32)18-13-21(36-3)24(38-5)25(39-6)22(18)28-29-31/h11-13,17H,7-10,14-15H2,1-6H3

HIDE SMILES / InChI

Description
Sources: https://www.researchgate.net/publication/16001834_Pharmacological_profile_of_razinodil_as_a_possible_new_drug_for_ischemic_myocardial_diseases | https://pubchem.ncbi.nlm.nih.gov/compound/Razinodil
Curator's Comment: Publication in URI also on PubMed, but title only: https://www.ncbi.nlm.nih.gov/pubmed/7196735

Razinodil was developed as a coronary vasodilator, a drug that reduces blood pressure by dilating blood vessels. It was tested for its potential as a drug in ischemic myocardial diseases. In a canine heart-lung laboratory model, it increased coronary blood flow without increasing oxygen consumption. Only slight negative chronotropic (heart rate) and inotropic (cardiac contraction) effects were reported. Razinodil also improved the survival rate of miniature pigs after an induced heart attack.

Approval Year

Name

Type

Language

RAZINODIL

Official Name

English

razinodil [INN]

Common Name

English

NSC-310409

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29707