ACLATONIUM

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H20NO4
Molecular Weight	218.2701
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	1

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Structure Search

SMILES

CC(OC(C)=O)C(=O)OCC[N+](C)(C)C

InChI

InChIKey=SRZGFCNCQUMTCP-UHFFFAOYSA-N

InChI=1S/C10H20NO4/c1-8(15-9(2)12)10(13)14-7-6-11(3,4)5/h8H,6-7H2,1-5H3/q+1

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Description
Sources: https://www.jstage.jst.go.jp/article/tonyobyo1958/32/4/32_4_237/_pdf

Aclatonium (also known as aclatonium napadisilate) is a cholinergic agonist that has been developed and used in Asia as an activator of gastrointestinal motility.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Effect of acetylcholine and new cholinergic derivative on amylase output, insulin, glucagon, and somatostatin secretions from perfused isolated rat pancreas.	1982 Jul	6180966
The effect of a new synthetic cholinergic compound (aclatonium napadisilate) on interdigestive motility and pancreatic function in humans.	1989 Oct	2476520

Patents

Sample Use Guides

In Vivo Use Guide

Aclatonium should be given at the dosage of 300 mg/day.

Route of Administration: Other

In Vitro Use Guide

The effect of aclotonium on exocrine pancreatic secretion and insulin release was investigated in the isolated, perfused rat pancreas. The effect of the drug on insulin release was detectable at a concentration of 0.1uM, while the increase in exocrine secretion was observed at 1.0 uM.

Name

Type

Language

ACLATONIUM

Common Name

English

ACLATONIUM ION

Common Name

English

2-(2-(ACETYLOXY)-1-OXOPROPOXY)-N,N,N-TRIMETHYLETHANAMINIUM

Systematic Name

English

Aclatonium [WHO-DD]

Common Name

English

ACLATONIUM CATION

Common Name

English

CHOLINE LACTATE, ACETATE

Systematic Name

English

ETHANAMINIUM, 2-(2-(ACETYLOXY)-1-OXOPROPOXY)-N,N,N-TRIMETHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796