ACLATONIUM NAPADISILATE

Details

Stereochemistry	RACEMIC
Molecular Formula	2C10H20NO4.C10H6O6S2
Molecular Weight	722.821
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(OC(C)=O)C(=O)OCC[N+](C)(C)C.CC(OC(C)=O)C(=O)OCC[N+](C)(C)C.[O-]S(=O)(=O)C1=CC=CC2=C(C=CC=C12)S([O-])(=O)=O

InChI

InChIKey=HELVYVGHOJPCEV-UHFFFAOYSA-L

InChI=1S/2C10H20NO4.C10H8O6S2/c2*1-8(15-9(2)12)10(13)14-7-6-11(3,4)5;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16/h2*8H,6-7H2,1-5H3;1-6H,(H,11,12,13)(H,14,15,16)/q2*+1;/p-2

HIDE SMILES / InChI

Molecular Formula	C10H20NO4
Molecular Weight	218.2701
Charge	1
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	C10H6O6S2
Molecular Weight	286.281
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.jstage.jst.go.jp/article/tonyobyo1958/32/4/32_4_237/_pdf

Aclatonium (also known as aclatonium napadisilate) is a cholinergic agonist that has been developed and used in Asia as an activator of gastrointestinal motility.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Aclatonium should be given at the dosage of 300 mg/day.

Route of Administration: Other

In Vitro Use Guide

The effect of aclotonium on exocrine pancreatic secretion and insulin release was investigated in the isolated, perfused rat pancreas. The effect of the drug on insulin release was detectable at a concentration of 0.1uM, while the increase in exocrine secretion was observed at 1.0 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:28:34 GMT 2023` Edited by `admin` on `Fri Dec 15 17:28:34 GMT 2023`
Record UNII	YX23434YHQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACLATONIUM NAPADISILATE

Official Name

English

1,5-NAPHTHALENEDISULFONIC ACID, ION(2-), BIS(2-(2-(ACETYLOXY)-1-OXOPROPOXY)-N,N,N-TRIMETHYLETHANAMINIUM)

Common Name

English

CHOLINE 1,5-NAPHTHALENEDISULPHONATE (2:1), DILACTATE, DIACETATE

Common Name

English

ACLATONIUM NAPADISILATE [MI]

Common Name

English

ETHANAMINIUM, 2-(2-(ACETYLOXY)-1-OXOPROPOXY)-N,N,N-TRIMETHYL-, 1,5-NAPHTHALENEDISULFONATE (2:1)

Common Name

English

ETHANAMINIUM, 2-(2-(ACETYLOXY)-1-OXOPROPOXY)-N,N,N-TRIMETHYL-, 1,5-NAPHTHALENEDISULPHONATE (2:1)

Common Name

English

aclatonium napadisilate [INN]

Common Name

English

Aclatonium napadisilate [WHO-DD]

Common Name

English

ACLATONIUM NAPADISILATE [MART.]

Common Name

English

ACLATONIUM NAPADISILATE [JAN]

Common Name

English

TM 723

Code

English

ACLATONIUM NAPADISYLATE

Common Name

English

TM-723

Code

English

CHOLINE 1,5-NAPHTHALENEDISULFONATE (2:1), DILACTATE, DIACETATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796