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Details

Stereochemistry ACHIRAL
Molecular Formula 3C6H5O7.4Fe.3O7P2.9H
Molecular Weight 1321.581
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC PYROPHOSPHATE CITRATE

SMILES

[H+].[H+].[H+].[H+].[H+].[H+].[H+].[H+].[H+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=SXAWSYZURCZSDX-UHFFFAOYSA-B
InChI=1S/3C6H8O7.4Fe.3H4O7P2/c3*7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;3*1-8(2,3)7-9(4,5)6/h3*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;;3*(H2,1,2,3)(H2,4,5,6)/q;;;4*+3;;;/p-12

HIDE SMILES / InChI

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
Biological availability of iron supplements for rats, chicks and humans.
1976 Feb
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010 Dec 7
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.
2016 Feb 14
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
FERRIC PYROPHOSPHATE CITRATE
USAN   WHO-DD  
USAN  
Official Name English
SOLUBLE FERRIC PYROPHOSPHATE
Common Name English
H-61
Code English
Ferric pyrophosphate citrate [WHO-DD]
Common Name English
TRIFERIC
Brand Name English
TRIFERIC AVNU
Brand Name English
FERRIC PYROPHOSPHATE CITRATE [ORANGE BOOK]
Common Name English
SFP
Common Name English
FERRIC PYROPHOSPHATE CITRATE [USAN]
Common Name English
FERRIC PYROPHOSPHATE, SOLUBLE
Common Name English
Tetraferric nonahydrogen citrate pyrophosphate
Common Name English
H61
Code English
Code System Code Type Description
DAILYMED
UBY79OCO9G
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
DRUG CENTRAL
5122
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
FDA UNII
UBY79OCO9G
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
USAN
CD-56
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
CAS
1275612-31-1
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
NO STRUCTURE GIVEN
LACTMED
Ferric Pyrophosphate Citrate
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
NCI_THESAURUS
C169976
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
EVMPD
SUB32445
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
DRUG BANK
DB13995
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
SMS_ID
300000017556
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
CAS
1802359-96-1
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
PUBCHEM
109374151
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
RXCUI
1607975
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL3544987
Created by admin on Sat Dec 16 00:26:10 GMT 2023 , Edited by admin on Sat Dec 16 00:26:10 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of FERRIC CATION
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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