PROPETAMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H22N2O2
Molecular Weight	250.3367
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCNC(=O)C(C)NC1=CC=C(OCC)C=C1

InChI

InChIKey=VVUMWAHNKOLVSN-UHFFFAOYSA-N

InChI=1S/C14H22N2O2/c1-4-10-15-14(17)11(3)16-12-6-8-13(9-7-12)18-5-2/h6-9,11,16H,4-5,10H2,1-3H3,(H,15,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5875767 | https://www.ncbi.nlm.nih.gov/pubmed/17403952 | Archives Internationales de Pharmacodynamie et de Therapie (1966), 164, (2), 340-4.

Propetamide (also known as FC 379) is a propionamide derivative patented by All-Union Scientific Research Chemical-Pharmaceutical Institute as an analgesic compound. In mice, Propetamide produced both a depression of spontaneous motility and relaxation of muscular tone. However, Propetamide was less active than meprobamate. Propetamide at 400 mg/kg reduced muscular relaxation in 70% of the animals, while the same effect was obtained in 100% of the animals with meprobamate at 200 mg/kg.

Originator

Approval Year

PubMed

Title	Date	PubMed
[On the metabolism of N-n-propyl-alpha-p-phenetidine-propionamide (PFP) in man. Preliminary note].	1964-02-15	5875767

Patents

Sample Use Guides

In Vivo Use Guide

rat: 300-400 mg/kg

Route of Administration: Oral

Name

Type

Language

PROPETAMIDE

Official Name

English

FC-379

Preferred Name

English

N-PROPYL-.ALPHA.-P-PHENETIDINEPROPIONAMIDE

Common Name

English

(±)-.ALPHA.-P-ETHOXYPHENYLAMINO-N-PROPYLPROPIONAMIDE

Common Name

English

PROPIONAMIDE, 2-P-PHENETIDINO-N-PROPYL-

Common Name

English

PROPANAMIDE, 2-((4-ETHOXYPHENYL)AMINO)-N-PROPYL-

Systematic Name

English

propetamide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241