PRIZIDILOL HYDROCHLORIDE ANHYDROUS

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H25N5O2.2ClH
Molecular Weight	404.335
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PRIZIDILOL HYDROCHLORIDE ANHYDROUS

Structure Search

SMILES

Cl.Cl.CC(C)(C)NCC(O)COC1=CC=CC=C1C2=NN=C(NN)C=C2

InChI

InChIKey=JXYMAOJZCNBDTB-UHFFFAOYSA-N

InChI=1S/C17H25N5O2.2ClH/c1-17(2,3)19-10-12(23)11-24-15-7-5-4-6-13(15)14-8-9-16(20-18)22-21-14;;/h4-9,12,19,23H,10-11,18H2,1-3H3,(H,20,22);2*1H

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6196556 | https://www.ncbi.nlm.nih.gov/pubmed/6151998 | https://www.ncbi.nlm.nih.gov/pubmed/2427813 | https://www.ncbi.nlm.nih.gov/pubmed/6151553 | https://www.ncbi.nlm.nih.gov/pubmed/7188585

Prizidilol (also known as SKF 92657) is arylpyridazinylhydrazine derivative patented by Smith Kline and French Laboratories Ltd. as an antihypertensive agent. In clinical trials, Supine and standing blood pressure measured 24--27 h after drug intake was reduced Slight but significant decreases in heart rate were seen after moderate doses of prizidilol. A more pronounced blood pressure reduction was noticed 2--7 h after drug administration. Prizidilol was well tolerated, although dizziness and tiredness were reported by four patients and edema by two.

Originator

Approval Year

PubMed

Title	Date	PubMed
Clinical pharmacology and pharmacokinetics of prizidilol in hypertensive patients.	1983-11-01	6196556
Studies on the autonomic nervous system with SK&F 92657, a new antihypertensive agent causing direct arterial vasodilatation and beta-adrenoceptor blockade.	1981-03-01	6166806
Hemodynamic profile of a new antihypertensive agent D,L-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine (SK&F 92657).	1981-03-01	6166805
SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade.	1979-12	44235

Patents

Sample Use Guides

In Vivo Use Guide

600 mg

Route of Administration: Oral

Name

Type

Language

PRIZIDILOL HYDROCHLORIDE ANHYDROUS

Common Name

English

3(2H)-PYRIDAZINONE, 6-(2-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)PHENYL)-, HYDRAZONE, DIHYDROCHLORIDE, (±)-

Preferred Name

English

2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-(2-(6-HYDRAZINYL-3-PYRIDAZINYL)PHENOXY)-, HYDROCHLORIDE (1:2)

Systematic Name

English

3(2H)-PYRIDAZINONE, 6-(2-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)PHENYL)-, HYDRAZONE, DIHYDROCHLORIDEHYDROXYPROPOXY)PHENYL)-, HYDRAZONE, DIHYDROCHLORIDE, MONOHYDRATE

Common Name

English

Prizidilol hydrochloride anhydrous [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576