Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H17NO2 |
| Molecular Weight | 267.3224 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CCC3=C(C=C(O)C(O)=C3)[C@]1([H])C4=C(CN2)C=CC=C4
InChI
InChIKey=BGOQGUHWXBGXJW-YOEHRIQHSA-N
InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m0/s1
Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. Dihydrexidine was shown to stimulate cyclic AMP synthesis just as well or better than dopamine. It was the first dopamine D1 receptor agonist that had potent antiparkinsonian activity in a primate model of Parkinson's disease. Dihydrexidine produces hypothermia. Dihydrexidine has been shown to alleviate cognitive deficits or enhance cognitive performance in a number of animal models of cognition. It is under investigation for the improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. | 2001 Feb |
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| Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. | 2002 Sep 15 |
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| A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine D(1/5) receptors in the prefrontal cortex? | 2004 |
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| Effects of dopamine D1 receptor full agonists in rats trained to discriminate SKF 38393. | 2004 Feb |
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| Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. | 2005 Oct |
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| Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. | 2011 Aug 11 |
Patents
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757161-85-6
Created by
admin on Sat Dec 16 14:22:57 GMT 2023 , Edited by admin on Sat Dec 16 14:22:57 GMT 2023
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U4MPC92UC2
Created by
admin on Sat Dec 16 14:22:57 GMT 2023 , Edited by admin on Sat Dec 16 14:22:57 GMT 2023
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5311070
Created by
admin on Sat Dec 16 14:22:57 GMT 2023 , Edited by admin on Sat Dec 16 14:22:57 GMT 2023
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ACTIVE MOIETY
