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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H29N3O5
Molecular Weight 367.44
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BAMBUTEROL, (R)-

SMILES

CN(C)C(=O)OC1=CC(=CC(OC(=O)N(C)C)=C1)[C@@H](O)CNC(C)(C)C

InChI

InChIKey=ANZXOIAKUNOVQU-HNNXBMFYSA-N
InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3/t15-/m0/s1

HIDE SMILES / InChI

Description

(R)-Bambuterol is a selective β2-adrenoceptor agonist. R-Bambuterol Hydrochloride Tablets ("Laevo-Bambuterol") is categorized as a Class 1 new drug. Its preclinical studies show that it is more effective and have lower toxicity than Bambuterol, a popular asthma drug currenTLy on the market. Laevo-Bambuterol was approved by the China Food and Drug Administration for the treatment of asthma.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
0.56 mM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
149.2 ng/L
2.5 mg single, oral
(R)-BAMBUTEROL plasma
Homo sapiens
1136 ng/L
10 mg single, oral
(R)-BAMBUTEROL plasma
Homo sapiens
419.4 ng/L
5 mg single, oral
(R)-BAMBUTEROL plasma
Homo sapiens

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Single dose (2.5 mg, 5 mg or 10 mg) or multiple doses (5 mg) for 7 days
Route of Administration: Oral
In Vitro Use Guide
Unknown