VERDIPERSTAT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H15N3O2S
Molecular Weight	253.321
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)OCCN1C2=C(NC=C2)C(=O)NC1=S

InChI

InChIKey=FVJCUZCRPIMVLB-UHFFFAOYSA-N

InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)

HIDE SMILES / InChI

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT02388295 | https://www.ncbi.nlm.nih.gov/pubmed/29873817 | https://www.biohavenpharma.com/investors/news-events/press-releases/02-19-2019

Verdiperstat (formerly known as AZD 3241) was developed as a selective inhibitor of myeloperoxidase, an enzyme that acts as a key driver of pathological oxidative stress and inflammation in the brain. Verdiperstat was studied in patients with a number of neurodegenerative disorders, including multiple system atrophy and Parkinson's disease. Verdiperstat participated in phase II clinical trials for both diseases. As a result, studies for Parkinson disease were discontinued. In the case of multiple system atrophy, the drug has received the orphan drug status.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Drug: AZD3241 administered for 12 weeks orally as a tablet.

Route of Administration: Oral

Name

Type

Language

VERDIPERSTAT

Official Name

English

verdiperstat [INN]

Common Name

English

AZD 3241 [WHO-DD]

Common Name

English

1-(2-ISOPROPOXYETHYL)-2-THIOXO-1,2,3,5-TETRAHYDROPYRROLO(3,2-D)PYRIMIDIN-4-ONE

Systematic Name

English

1-(2-ISOPROPOXYETHYL)-2-THIOXO-1,2,3,5-TETRAHYDRO-PYRROLO(3,2-D) PYRIMIDIN-4-ONE

Systematic Name

English

AZD-3241

Common Name

English

VERDIPERSTAT [USAN]

Common Name

English

AZD3241

Code

English

Verdiperstat [WHO-DD]

Common Name

English

BHV-3241

Code

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/14/1404