Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H7AsNO3.Na.4H2O |
Molecular Weight | 311.0972 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.O.[Na+].NC1=CC=C(C=C1)[As](O)([O-])=O
InChI
InChIKey=IQHDBXORJXXEFF-UHFFFAOYSA-M
InChI=1S/C6H8AsNO3.Na.4H2O/c8-6-3-1-5(2-4-6)7(9,10)11;;;;;/h1-4H,8H2,(H2,9,10,11);;4*1H2/q;+1;;;;/p-1
DescriptionSources: http://www.who.int/trypanosomiasis_african/country/history/en/index6.html | https://www.ncbi.nlm.nih.gov/pubmed/24251577 | https://www.ncbi.nlm.nih.gov/pubmed/920189 | https://www.ncbi.nlm.nih.gov/pubmed/3742372https://www.ncbi.nlm.nih.gov/pubmed/24136205Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/20763444 | https://www.ncbi.nlm.nih.gov/pubmed/21772505 | https://www.ncbi.nlm.nih.gov/pubmed/20219092
Sources: http://www.who.int/trypanosomiasis_african/country/history/en/index6.html | https://www.ncbi.nlm.nih.gov/pubmed/24251577 | https://www.ncbi.nlm.nih.gov/pubmed/920189 | https://www.ncbi.nlm.nih.gov/pubmed/3742372https://www.ncbi.nlm.nih.gov/pubmed/24136205
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/20763444 | https://www.ncbi.nlm.nih.gov/pubmed/21772505 | https://www.ncbi.nlm.nih.gov/pubmed/20219092
Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound first reported in 1863 by Antoine Béchamp. Arsanilic acid is a crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, Arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the chemotherapeutic approach to treating infectious diseases of humans.
Originator
Sources: http://www.who.int/trypanosomiasis_african/country/history/en/index6.html | https://www.ncbi.nlm.nih.gov/pubmed/16103665M. A. Bechamp (1863). Compt. Rend. 56: 1172–1175.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Treponema pallidum Sources: https://www.ncbi.nlm.nih.gov/pubmed/19868094 |
|||
Target ID: WP1018 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23848144 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Atoxyl Approved UseAfrican trypanosomiasis |
|||
Primary | Atoxyl Approved UseSyphilis |
|||
Curative | Atoxyl Approved UseUnknown |
|||
Primary | Atoxyl Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Hippocampal and striatal M(1) -muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats. | 2016 Dec |
|
Effects of bilateral vestibular deafferentation in rat on hippocampal theta response to somatosensory stimulation, acetylcholine release, and cholinergic neurons in the pedunculopontine tegmental nucleus. | 2017 Sep |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4272953
Pigs: 161 mg/liter in drinking water for seven days
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.innovativesolution.it/atoxyl.htm
In cultures of retina in vitro, addition of 5X10-3 M sodium arsanilate has caused degeneration of the rod cells
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
TFX0FRW3R1
Created by
admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
|
PRIMARY | |||
|
6696-54-4
Created by
admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
|
PRIMARY | |||
|
23719536
Created by
admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
|
PRIMARY | |||
|
DTXSID90217160
Created by
admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD