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Details

Stereochemistry ACHIRAL
Molecular Formula C6H7AsNO3.Na.4H2O
Molecular Weight 311.0972
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM ARSANILATE TETRAHYDRATE

SMILES

O.O.O.O.[Na+].NC1=CC=C(C=C1)[As](O)([O-])=O

InChI

InChIKey=IQHDBXORJXXEFF-UHFFFAOYSA-M
InChI=1S/C6H8AsNO3.Na.4H2O/c8-6-3-1-5(2-4-6)7(9,10)11;;;;;/h1-4H,8H2,(H2,9,10,11);;4*1H2/q;+1;;;;/p-1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/20763444 | https://www.ncbi.nlm.nih.gov/pubmed/21772505 | https://www.ncbi.nlm.nih.gov/pubmed/20219092

Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound first reported in 1863 by Antoine Béchamp. Arsanilic acid is a crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, Arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the chemotherapeutic approach to treating infectious diseases of humans.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Hippocampal and striatal M(1) -muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats.
2016 Dec
Effects of bilateral vestibular deafferentation in rat on hippocampal theta response to somatosensory stimulation, acetylcholine release, and cholinergic neurons in the pedunculopontine tegmental nucleus.
2017 Sep
Patents

Sample Use Guides

Pigs: 161 mg/liter in drinking water for seven days
Route of Administration: Oral
In Vitro Use Guide
In cultures of retina in vitro, addition of 5X10-3 M sodium arsanilate has caused degeneration of the rod cells
Name Type Language
SODIUM ARSANILATE TETRAHYDRATE
Common Name English
ARSONIC ACID, (4-AMINOPHENYL)-, MONOSODIUM SALT, TETRAHYDRATE
Systematic Name English
ARSANILIC ACID, MONOSODIUM SALT, TETRAHYDRATE
Common Name English
AS-(4-AMINOPHENYL)ARSONIC ACID SODIUM SALT TETRAHYDRATE
MI  
Systematic Name English
AS-(4-AMINOPHENYL)ARSONIC ACID SODIUM SALT TETRAHYDRATE [MI]
Common Name English
Code System Code Type Description
FDA UNII
TFX0FRW3R1
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
CAS
6696-54-4
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
PUBCHEM
23719536
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
EPA CompTox
DTXSID90217160
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY