Phthalofyne was given to 10 healthy young Filipino males harboring Trichuris trichiura. Of 7 cases who received 100 to 125 mg./kg. by mouth, alone or in combination with the same dose given by enema, 4 had rather minimal complaints of nausea and/or vomiting and none received significant therapeutic benefit. The highest oral dose, 175 mg./kg. given to a single patient, produced considerable nausea and apparently complete regurgitation of gastric contents and no therapeutic benefit, suggesting that effective single oral doses would not be easily retained. The phthalofyne enemas, containing respectively 200 mg./kg. and 450 mg./kg. of the drug, and given one week apart to a single patient, produced no side effects and no significant therapeutic effect.

Unknown