| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H12O6 |
| Molecular Weight | 180.1559 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO
InChI
InChIKey=BJHIKXHVCXFQLS-PQLUHFTBSA-N
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5+,6-/m1/s1
Tagatose is a functional sweetener. It is naturally occurring and often found in dairy products. Tagatose is similar in texture and sweetness to sucrose (table sugar) but with only 38% of the calories. It is approved for use as a food additive as a low-calorie sweetener. Only 15 - 20 % of Tagatose is absorbed in the small intestines and metabolized similarly to sucrose; the bulk of ingested tagatose is fermented in the colon by bacteria producing short chain fatty acids which are subsequently absorbed and metabolized by the body without affecting insulin levels. Tagatose is being investigated by Spherix for the treatment of obesity and type II diabetes. Tagatose consumed orally significantly blunts the rise in plasma glucose seen after oral glucose in patients with diabetes mellitus in a dose-dependent manner without significantly affecting insulin levels. It has been suggested that Tagatose may act by attenuating the absorption of glucose in the intestines.
Approval Year
Sourcing
PubMed
Patents
Sample Use Guides
Patients with type II diabetes were instructed to consume 15 grams of tagatose dissolved in water every day for one year.
Route of Administration:
Oral
A clinically isolated strain of Streptococcus mutans GS5 was grown in TY medium at 37 deg-C for 24 hours. After 24 hours the culture was diluted to OD600 = 0.3 and inoculated into a solution of 10% w/v Tagatose in TY medium (with and without 1% w/v sucrose). The inoculated tagatose solution was incubated at 37 deg C and OD600 measured at 4, 8, 12, and 20 hours. The pH of the inoculated solution was measured at 12 hours. d-tagatose significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1% sucrose, and the inhibitory effect of acid production by D-tagatose was significantly stronger that of xylitol in presence of sucrose.
ACTIVE MOIETY
