SULFACYTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N4O3S
Molecular Weight	294.33
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC1=O

InChI

InChIKey=SIBQAECNSSQUOD-UHFFFAOYSA-N

InChI=1S/C12H14N4O3S/c1-2-16-8-7-11(14-12(16)17)15-20(18,19)10-5-3-9(13)4-6-10/h3-8H,2,13H2,1H3,(H,14,15,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/769287

Sulfacytine is a short-acting sulfonamide, which was used for the treatment uncomplicated urinary tract infections, but was discontinued. This drug is a is a competitive inhibitor of the dihydropteroate synthetase, that inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the peridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dihydropteroate synthetase 10 Target ID: CHEMBL2013 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1195474	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Uncomplicated urinary tract infections 7 Sources: https://www.ncbi.nlm.nih.gov/pubmed/769287	Curative		Approved 8583	RENOQUID Approved Use Unknown Launch Date 1975

T_1/2

Value	Dose	Co-administered	Analyte	Population
4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3606051/	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:		SULFACYTINE plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
14% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3606051/	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:		SULFACYTINE plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY532282	https://www.001chemical.com/chem/17784-12-2
Achemtek	0102-014462	http://www.achemtek.com/17784-12-2
Ambinter	Amb22734739	http://www.ambinter.com/reference/22734739
BLD Pharm	BD152142	http://www.bldpharm.com/products/17784-12-2.html
Chem Scene	CS-0006353	http://www.chemscene.com/17784-12-2.html
ChemMol	49400456	http://www.chemmol.com/chemmol/49400456.html
Debye Scientific	DA-09179	http://www.debyesci.com/cas_17784-12-2.html
eNovation Chemicals	D674590	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674590
Finetech	FT-0710995	http://www.finetechnology-ind.com/prod/detail/pub/17784-12-2.html
MedChem Express	HY-16472	https://www.medchemexpress.com/sulfacytine.html
Molcore	MC532282	https://www.molcore.com/product/17784-12-2
MuseChem	M133124	https://www.musechem.com/product/M133124.html
Smolecule	S544110	http://www.smolecule.com/products/s544110
Smolecule	S793342	https://www.smolecule.com/products/s793342
THE BioTek	bt-282721	https://www.thebiotek.com/product/inhibitors/bt-282721
THE BioTek	bt-406972	https://www.thebiotek.com/product/others/bt-406972

PubMed

Title	Date	PubMed
Sulfacytine vs. sulfisoxazole for urinary tract infections in an obstetric-gynecologic population.	1976-06	819216
Sulfacytine in uncomplicated urinary tract infections. Double-blind comparison with sulfisoxazole.	1976-03	769287
Double-blind comparison of sulfacytine, a new sulfonamide, with sulfisoxazole in acute uncomplicated urinary tract infections.	1976-02	813961
Sulfacytine: a new sulfonamide. Double-blind comparison with sulfisoxazole in acute uncomplicated urinary tract infections.	1975-12	1195474

Patents

Sample Use Guides

In Vivo Use Guide

1Gm per day

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

SULFACITINE

Preferred Name

English

SULFACYTINE

Official Name

English

sulfacitine [INN]

Common Name

English

SULFACYTINE [HSDB]

Common Name

English

NSC-356717

Code

English

N-SULFANILYL-1-ETHYLCYTOSINE

Systematic Name

English

1-ETHYL-N-SULFANILYLCYTOSINE

Systematic Name

English

RENOQUID

Brand Name

English

SULFANILAMIDE, N1-(1-ETHYL-1,2-DIHYDRO-2-OXO-4-PYRIMIDINYL)-

Systematic Name

English

N(SUP 1)-(1-ETHYL-1,2-DIHYDRO-2-OXO-4-PYRIMIDINYL)SULFANILAMIDE

Systematic Name

English

SULFACYTINE [MART.]

Common Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(1-ETHYL-1,2-DIHYDRO-2-OXO-4-PYRIMIDINYL)-

Systematic Name

English

CI-636

Code

English

SULFACYTINE [VANDF]

Common Name

English

SULFACYTINE [MI]

Common Name

English

SULFACYTINE [USAN]

Common Name

English

SULFACYTINE [ORANGE BOOK]

Common Name

English

Sulfacitine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29739