Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C26H34O3 |
Molecular Weight | 394.5464 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](OC(=O)C3=CC=CC=C3)[C@@]1(C)CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])CC(=O)CC[C@]45C
InChI
InChIKey=ZGDZDAPCWHIIKB-LVYWIKMTSA-N
InChI=1S/C26H34O3/c1-25-14-12-19(27)16-18(25)8-9-20-21-10-11-23(26(21,2)15-13-22(20)25)29-24(28)17-6-4-3-5-7-17/h3-7,18,20-23H,8-16H2,1-2H3/t18-,20-,21-,22-,23-,25-,26-/m0/s1
STANOLONE, also known as dihydrotestosterone, is a potent androgenic metabolite of testosterone and anabolic agent for systemic use. It may be used as a replacement of male sex steroids in men who have androgen deficiency, for example as a result of the loss of both testes, and also the treatment of certain rare forms of aplastic anemia which are or may be responsive to anabolic androgens.
Approval Year
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7.8 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9709942/ |
16 mg single, topical dose: 16 mg route of administration: Topical experiment type: SINGLE co-administered: |
STANOLONE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
44.8 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9709942/ |
16 mg single, topical dose: 16 mg route of administration: Topical experiment type: SINGLE co-administered: |
STANOLONE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
12 day EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9709942/ |
16 mg single, topical dose: 16 mg route of administration: Topical experiment type: SINGLE co-administered: |
STANOLONE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
2% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1778174/ |
unknown, unknown |
STANOLONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
250 mg 1 times / day multiple, transdermal Highest studied dose Dose: 250 mg, 1 times / day Route: transdermal Route: multiple Dose: 250 mg, 1 times / day Sources: |
healthy, 58 years (range: 50-70 years) n = 60 Health Status: healthy Age Group: 58 years (range: 50-70 years) Sex: M Population Size: 60 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
inconclusive [Activation 15.8489 uM] | ||||
no [Activation >15.8489 uM] | ||||
no [IC50 >10 uM] | ||||
no [IC50 >10 uM] | ||||
no [IC50 >10 uM] | ||||
no [IC50 >10 uM] | ||||
no [IC50 >10 uM] | ||||
no [IC50 >10 uM] | ||||
yes | ||||
yes | ||||
yes |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
likely | ||||
major [Km 5.7 uM] | ||||
major | ||||
minor [Km 382.3 uM] | ||||
minor [Km 78.9 uM] | ||||
minor | ||||
no | ||||
no | ||||
no | ||||
no | ||||
no | ||||
no | ||||
no | ||||
weak [Km 676.4 uM] | ||||
weak | ||||
yes [Km 2.6 uM] | ||||
yes | ||||
yes | ||||
yes | ||||
yes | ||||
yes | ||||
yes | ||||
yes | ||||
yes | ||||
yes |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/18599551/ |
||||
PubMed
Title | Date | PubMed |
---|---|---|
The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. | 1999 Jan-Mar |
|
Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. | 2000 Feb |
|
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. | 2000 Jan |
|
Differential estrogen receptor binding of estrogenic substances: a species comparison. | 2000 Nov 15 |
|
Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. | 2000 Sep 1 |
|
Aromatase inhibition reduces specifically one display of the ring dove courtship behavior. | 2001 Apr |
|
Antitumor effect of an HER2-specific antibody-toxin fusion protein on human prostate cancer cells. | 2001 Apr |
|
Oral contraceptives in the treatment of acne. | 2001 Feb |
|
Effects of the anti-androgen finasteride on the modulatory actions of oestradiol on androgen metabolism by human gingival fibroblasts. | 2001 Feb |
|
Biochemical roles of testosterone and epitestosterone to 5 alpha-reductase as indicators of male-pattern baldness. | 2001 Jan |
|
Maternal steroids and contaminants in common tern eggs: a mechanism of endocrine disruption? | 2001 Jan |
|
The octadecaneuropeptide ODN stimulates neurosteroid biosynthesis through activation of central-type benzodiazepine receptors. | 2001 Jan |
|
Comparison of histological compositions and apoptosis in canine spontaneous benign prostatic hyperplasia treated with androgen suppressive agents chlormadinone acetate and finasteride. | 2001 Jan |
|
Sex steroid hormones enhance immune function in male and female Siberian hamsters. | 2001 Jan |
|
Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. | 2001 Jun 22 |
|
3alpha-Hydroxysteroid dehydrogenase in animal and human tissues. | 2001 Mar |
|
Age and gender specific stimulation of creatine kinase specific activity by gonadal steroids in human bone-derived cells in culture. | 2001 Mar |
|
Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males. | 2001 Mar |
|
Sex-dependent regulation by dexamethasone of murine hydroxysteroid sulfotransferase gene expression. | 2001 Mar 8 |
|
Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia. | 2001 May |
|
Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction. | 2001 May 15 |
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Classification Tree | Code System | Code | ||
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DEA NO. |
4000
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213-891-8
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1057-07-4
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69549
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T74307G2D9
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300000028081
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ACTIVE MOIETY
SUBSTANCE RECORD