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Details

Stereochemistry RACEMIC
Molecular Formula C21H27NO3S2.ClH.H2O
Molecular Weight 460.05
Optical Activity ( + / - )
Defined Stereocenters 0 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAZATICOL HYDROCHLORIDE MONOHYDRATE

SMILES

O.Cl.CN1C2CCC(C)(C)C1CC(C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=ISDSJXYEVLNWPV-UHFFFAOYSA-N
InChI=1S/C21H27NO3S2.ClH.H2O/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18;;/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3;1H;1H2

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167, https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm

Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PENTONA

Approved Use

Parkinson's syndrome due to psychotropic drug administration
PubMed

PubMed

TitleDatePubMed
Pharmacology of a new anti-parkinsonian drug: KAO-264.
1971 Apr
[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent].
1971 Jul
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.
1982
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.
1990 Sep
Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.
2002

Sample Use Guides

1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: the full-text can be found here: https://www.jstage.jst.go.jp/article/fpj1944/67/4/67_4_387/_pdf
Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.
Name Type Language
MAZATICOL HYDROCHLORIDE MONOHYDRATE
Common Name English
2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, 6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER, HYDROCHLORIDE, MONOHYDRATE, EXO-
Common Name English
MAZATICOL HYDROCHLORIDE HYDRATE [JAN]
Common Name English
MAZATICOL HYDROCHLORIDE HYDRATE
JAN  
Common Name English
Code System Code Type Description
PUBCHEM
11954326
Created by admin on Sat Dec 16 04:51:35 GMT 2023 , Edited by admin on Sat Dec 16 04:51:35 GMT 2023
PRIMARY
CAS
65104-02-1
Created by admin on Sat Dec 16 04:51:35 GMT 2023 , Edited by admin on Sat Dec 16 04:51:35 GMT 2023
PRIMARY
FDA UNII
T64234598Y
Created by admin on Sat Dec 16 04:51:35 GMT 2023 , Edited by admin on Sat Dec 16 04:51:35 GMT 2023
PRIMARY