GLISAMURIDE

Details

Stereochemistry	MIXED
Molecular Formula	C23H31N5O4S
Molecular Weight	473.588
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(CCNC(=O)N(C)C3=NC=CC=C3)C=C2

InChI

InChIKey=UIXYQZIHFQKFOZ-UHFFFAOYSA-N

InChI=1S/C23H31N5O4S/c1-17-6-10-19(11-7-17)26-22(29)27-33(31,32)20-12-8-18(9-13-20)14-16-25-23(30)28(2)21-5-3-4-15-24-21/h3-5,8-9,12-13,15,17,19H,6-7,10-11,14,16H2,1-2H3,(H,25,30)(H2,26,27,29)

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Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Glisamuride | https://www.ncbi.nlm.nih.gov/pubmed/6805052

Glisamuride is a hypoglycemic agent and part of the second-generation sulfonamide derivatives. Sulphonylureas are used as medication to control blood sugar levels in patients with diabetes type 2. Compared to other hypoglycemic agents, glisamuride exerts greater binding affinity for peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic activity. This type of compound has also been studied for effects on tumor growth. In one study, several sulfonyl urea derivates, among which glisamuride, were shown to inhibit the adherence of intravenously injected carcinosarcoma cells to the vascular endothelium of the rat mesentery, and to significantly reduce the rate of instantly occurring terminal tumor cell embolism of the lung.

Approval Year

Name

Type

Language

GLISAMURIDE

Official Name

English

1-METHYL-3-(P-((3-(4-METHYLCYCLOHEXYL)UREIDO)SULFONYL)PHENETHYL)-1-(2-PYRIDYL) UREA

Preferred Name

English

glisamuride [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C97936