Glisamuride is a hypoglycemic agent and part of the second-generation sulfonamide derivatives. Sulphonylureas are used as medication to control blood sugar levels in patients with diabetes type 2. Compared to other hypoglycemic agents, glisamuride exerts greater binding affinity for peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic activity. This type of compound has also been studied for effects on tumor growth. In one study, several sulfonyl urea derivates, among which glisamuride, were shown to inhibit the adherence of intravenously injected carcinosarcoma cells to the vascular endothelium of the rat mesentery, and to significantly reduce the rate of instantly occurring terminal tumor cell embolism of the lung.