Ensereptide (PXL01) is a polypeptide derived from human lactoferrin. PXL01 has several mechanisms of action; including immunomodulation and enhancement of fibrinolytic activity. PXL01 produces its immunomodulatory action by inhibiting the release of pro-inflammatory cytokines, such as IL-1β, IL-6 and Il-8 as well as TNF- α (tumor necrosis factor alpha). PXL01 also inhibits the local production of PAI-1 which is an important mediator of fibrinolysis. The anti-inflammatory properties combined with the modulation of fibrinolysis are assumed to account for the ability of the product candidate to prevent post-surgical adhesions and scar formation. Ensereptide (PXL01) is being developed by ProMore Pharma for the treatment of post-surgical adhesions and for prevention of dermal scarring after surgery or trauma.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat. | 2009 Dec |
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Effect of major abdominal surgery on the host immune response to infection. | 2010 Jun |
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A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits. | 2011 Oct |
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Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair. | 2012 Dec |
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PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial. | 2014 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25340801
20 mg/ml of PXL01 and 15 mg/ml of sodium hyaluronate. 0.5 ml of the mixed product was administered in the surgical area in flexor tendon repair surgery, corresponding to a dose of 10 mg PXL01.
Route of Administration:
Topical
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