U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Ensereptide (PXL01) is a polypeptide derived from human lactoferrin. PXL01 has several mechanisms of action; including immunomodulation and enhancement of fibrinolytic activity. PXL01 produces its immunomodulatory action by inhibiting the release of pro-inflammatory cytokines, such as IL-1β, IL-6 and Il-8 as well as TNF- α (tumor necrosis factor alpha). PXL01 also inhibits the local production of PAI-1 which is an important mediator of fibrinolysis. The anti-inflammatory properties combined with the modulation of fibrinolysis are assumed to account for the ability of the product candidate to prevent post-surgical adhesions and scar formation. Ensereptide (PXL01) is being developed by ProMore Pharma for the treatment of post-surgical adhesions and for prevention of dermal scarring after surgery or trauma.

Approval Year

PubMed

PubMed

TitleDatePubMed
A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat.
2009 Dec
Effect of major abdominal surgery on the host immune response to infection.
2010 Jun
A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits.
2011 Oct
Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair.
2012 Dec
PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial.
2014
Patents

Patents

Sample Use Guides

20 mg/ml of PXL01 and 15 mg/ml of sodium hyaluronate. 0.5 ml of the mixed product was administered in the surgical area in flexor tendon repair surgery, corresponding to a dose of 10 mg PXL01.
Route of Administration: Topical
Name Type Language
ENSEREPTIDE
INN  
INN  
Official Name English
PXL01
Code English
PXL-01
Code English
ACETYL(HUMAN LACTOTRANSFERRIN-(15-39)-PEPTIDAMIDE)
Common Name English
ensereptide [INN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C169952
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
FDA UNII
SMV73KW49C
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
PUBCHEM
49863418
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
CAS
254433-51-7
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
INN
9579
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
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