Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H8O2 |
Molecular Weight | 112.1265 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C\C=C\C(=O)OC=C
InChI
InChIKey=IYNRVIKPUTZSOR-HWKANZROSA-N
InChI=1S/C6H8O2/c1-3-5-6(7)8-4-2/h3-5H,2H2,1H3/b5-3+
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/5320882Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/5334792 | https://www.ncbi.nlm.nih.gov/pubmed/13962902 | DOI: 10.1021/j100700a014
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5320882
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/5334792 | https://www.ncbi.nlm.nih.gov/pubmed/13962902 | DOI: 10.1021/j100700a014
Malethamer is the generic name of a new synthetic hydrocarbon copolymer with extraordinary water-binding properties, being able to absorb 200 times its weight of water. It is physically and chemically binds poliovirus 1 and certain bacterial enterotoxins. Ethylene-maleic anhydride copolymers and their derivatives have come to be considered for a number of applications generally involving the formation of insoluble complexes with proteins and viruses. The copolymer is not absorbed from the gastrointestinal tract and is pharmacologically inert. Malethamer, because of its water absorbing quality, is an effective compound for the symptomatic control of diarrhea, both organic and functional.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5320882
Curator's Comment: # Eli Lilly
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Malethamer in the treatment of children with diarrhea. | 1965 Dec |
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The effect of maleic anhydride ethylene polymer (Malethamer) on intestinal motility. | 1966 Nov |
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Roentgen study of the comparative effect of malethamer and a placebo on gastrointestinal transit time in diarrheal states. | 1967 Feb |
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Experimental production of diarrhea and its prevention by Malethamer in monkeys. | 1967 Sep |
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Mechanism study of the action of Malethamer in staphylococcus enterotoxin-induced diarrhea in monkeys. | 1967 Sep |
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The effect of malethamer on the excretion and plasma levels of sodium, potassium, and chloride. | 1970 Oct |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5320882
500 mg after each bowel movement, but at least four times a day
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13962902
Ammoniated ethylene maleic anhydride copolymers and hydrolysed ethylene maleic anhydride copolymers of molecular weights approximating 120000 completely prevented cytopathogenicity at all Echo 9 virus concentrations (10-2 – 10-5).
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3234-54-6
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238-930-6
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5365800
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221-783-7
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DTXSID80864546
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14861-06-4
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5215
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m3858
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SMC9A01NVS
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SUBSTANCE RECORD