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Details

Stereochemistry ACHIRAL
Molecular Formula C6H8O2
Molecular Weight 112.1265
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of VINYL CROTONATE

SMILES

C\C=C\C(=O)OC=C

InChI

InChIKey=IYNRVIKPUTZSOR-HWKANZROSA-N
InChI=1S/C6H8O2/c1-3-5-6(7)8-4-2/h3-5H,2H2,1H3/b5-3+

HIDE SMILES / InChI

Molecular Formula C6H8O2
Molecular Weight 112.1265
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Malethamer is the generic name of a new synthetic hydrocarbon copolymer with extraordinary water-binding properties, being able to absorb 200 times its weight of water. It is physically and chemically binds poliovirus 1 and certain bacterial enterotoxins. Ethylene-maleic anhydride copolymers and their derivatives have come to be considered for a number of applications generally involving the formation of insoluble complexes with proteins and viruses. The copolymer is not absorbed from the gastrointestinal tract and is pharmacologically inert. Malethamer, because of its water absorbing quality, is an effective compound for the symptomatic control of diarrhea, both organic and functional.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
500 mg after each bowel movement, but at least four times a day
Route of Administration: Oral
In Vitro Use Guide
Ammoniated ethylene maleic anhydride copolymers and hydrolysed ethylene maleic anhydride copolymers of molecular weights approximating 120000 completely prevented cytopathogenicity at all Echo 9 virus concentrations (10-2 – 10-5).
Substance Class Chemical
Record UNII
SMC9A01NVS
Record Status Validated (UNII)
Record Version