OXOLAMINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H19N3O.ClH
Molecular Weight	281.781
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CC)CCC1=NC(=NO1)C2=CC=CC=C2

InChI

InChIKey=YHLIBHCNFDRYFW-UHFFFAOYSA-N

InChI=1S/C14H19N3O.ClH/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;/h5-9H,3-4,10-11H2,1-2H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup | https://www.ncbi.nlm.nih.gov/pubmed/13720535 | https://www.ncbi.nlm.nih.gov/pubmed/7140166

Oxolamine under brand names Symphocal, Perebron is used in some countries as a cough suppressant for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis, pertussis. Oxolamine possesses anti-inflammatory activity, which causes a reduction in the irritation of the nervous receptors of the respiratory tract.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Cough 106 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown
Tracheitis 3 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown
Bronchitis 51 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown
Pertussis 3 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown

PubMed

Title	Date	PubMed
Effect of oxolamine on cough sensitivity in COPD patients.	2002 Jan	11863211
Effect of oxolamine on anticoagulant effect of warfarin.	2006 Jan 15	16390929
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats.	2007 Apr	17295362

Patents

Sample Use Guides

In Vivo Use Guide

In general, 15-25 mg per kilogram per day should be given by dividing four equal doses. In children over 2 years: 1-2 ml of 5 ml Adults: 2 ml of 5 ml 4 times daily 4 hours a day, after an equal amount of water.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

OXOLAMINE HYDROCHLORIDE

Systematic Name

English

N,N-DIETHYL-3-PHENYL-1,2,4-OXADIAZOLE-5-ETHANAMINE HYDROCHLORIDE

Systematic Name

English

1,2,4-OXADIAZOLE-5-ETHANAMINE, N,N-DIETHYL-3-PHENYL-, MONOHYDROCHLORIDE

Common Name

English

1,2,4-OXADIAZOLE, 5-(2-(DIETHYLAMINO)ETHYL)-3-PHENYL-, MONOHYDROCHLORIDE

Common Name

English

OXOLAMINE HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m8313