SUPROFEN SODIUM

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H11O3S.Na
Molecular Weight	282.29
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[Na+].CC(C([O-])=O)C1=CC=C(C=C1)C(=O)C2=CC=CS2

InChI

InChIKey=ADTGIGSPQHDPLT-UHFFFAOYSA-M

InChI=1S/C14H12O3S.Na/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12;/h2-9H,1H3,(H,16,17);/q;+1/p-1

HIDE SMILES / InChI

Description

Suprafen is a dual inhibitor of COX-1 and COX-2, which was used for the inhibition of intraoperative miosis. Suprafen was marketed under the name Profenal, however, it is no longer available in the USA.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 1 30	Inhibitor 8,504		1.1 µM [IC50]
Prostaglandin G/H synthase 2 51	Inhibitor 8,504		8.3 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Intraoperative miosis 2	Preventing		Approved 8,583	PROFENAL

C_max

Value	Dose	Co-administered	Analyte	Population
18.95 μg/mL	200 mg single, oral		SUPROFEN plasma	Homo sapiens
8.43 μg/mL	200 mg single, oral		SUPROFEN plasma	Homo sapiens

AUC

Value	Dose	Co-administered	Analyte	Population
26.1 μg × h/mL	200 mg single, oral		SUPROFEN plasma	Homo sapiens
21.2 μg × h/mL	200 mg single, oral		SUPROFEN plasma	Homo sapiens

Doses

Show entries

Dose	Population	Adverse events
400 mg single, oral	unhealthy, > 18 years
600 mg single, oral Highest studied dose	healthy, adult
400 mg single, oral	healthy, adult	Other AEs: Nausea, Vomiting...

Showing 1 to 3 of 3 entries

Previous1Next

AEs

Show entries

AE	Significance	Dose	Population
Nausea	2 patients	400 mg single, oral	healthy, adult
Vomiting	2 patients	400 mg single, oral	healthy, adult

Showing 1 to 2 of 2 entries

Previous1Next

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
	substrate 1,193 inhibitor 2,438

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
UGT2B7 197

Drug as perpetrator

Show entries

Target	Modality	Activity	Metabolite	Clinical evidence
UGT2B7 210	inhibitor 4,027	likely
CYP2C9 2,497	inhibitor 4,027	yes [Ki 6.7 uM]

Showing 1 to 2 of 2 entries

Previous1Next

Drug as victim

Show entries

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2C9 1,193	substrate 4,014	yes

Showing 1 to 1 of 1 entries

Previous1Next

Sourcing

Sourcing

Show entries

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:9362	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:9362
ChemicalBook	CB2496867	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2496867
eMolecules	743277	https://www.emolecules.com/cgi-bin/more?vid=743277
MolPort	MolPort-001-791-811	https://www.molport.com/shop/molecule-link/MolPort-001-791-811
Selleck Chemicals	Suprofen(Profenal)	http://www.selleckchem.com/products/Suprofen(Profenal).html

Showing 1 to 5 of 5 entries

Previous1Next

PubMed

Show entries

Title	Date	PubMed
Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils.	1978 Nov	712644
Suprofen and renal failure.	1987 May	3565984
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.	2001 Nov	11792017
Effects of anti-inflammatory drugs and preservatives on morphologic characteristics and migration of canine corneal epithelial cells in tissue culture.	2002 Jun	12071871
Differential binding mode of diverse cyclooxygenase inhibitors.	2002 Mar	11885959

Showing 1 to 5 of 12 entries

Previous1 2 3Next

Patents

Sample Use Guides

In Vivo Use Guide

Administration of Profenal (1% solution of suprafen) begins the day before surgery: 2 drops every 4 hours. On the day of surgery two drops are placed in the eye 3, 2 and 1 hour before the procedure.

Route of Administration: Other

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

SUPROFEN SODIUM

Common Name

English

BENZENEACETIC ACID, .ALPHA.-METHYL-4-(2-THIENYLCARBONYL)-, SODIUM SALT

Preferred Name

English

BENZENEACETIC ACID, .ALPHA.-METHYL-4-(2-THIENYLCARBONYL)-, SODIUM SALT (1:1)

Systematic Name

English

Showing 1 to 3 of 3 entries

Previous1Next

Show entries

Code System

Code

Type

Description

PUBCHEM

23663698

PRIMARY

CAS

64382-50-9

SUPERSEDED

EPA CompTox

DTXSID10967236

PRIMARY

FDA UNII

S8LB9M91ST

PRIMARY

ECHA (EC/EINECS)

258-174-0

PRIMARY

Showing 1 to 5 of 6 entries

Previous1 2Next

PARENT (SALT/SOLVATE)


					988GU2F9PE

SUPROFEN

SUBSTANCE RECORD


					S8LB9M91ST

SUPROFEN SODIUM

SMILES

InChI

Originator

Approval Year

Targets

Conditions

Cmax

AUC

Doses

AEs

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

C_max

Drug as perpetrator