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Details

Stereochemistry ACHIRAL
Molecular Formula C10H10N2O
Molecular Weight 174.1992
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EDARAVONE

SMILES

CC1=NN(C(=O)C1)C2=CC=CC=C2

InChI

InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

HIDE SMILES / InChI

Description

Edaravone is a free radical scavenger developed for the treatment of amyotrophic lateral sclerosis.

CNS Activity

Originator

Approval Year

2017
131
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
907
Amyotrophic Lateral Sclerosis
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CHEMBL1689064: Hydroxyl Radical
Approved
7817
RADICUT
Primary
CHEMBL1689064: Hydroxyl Radical
Approved
7817
RADICUT
PubMed

PubMed

TitleDatePubMed
Protective effect of edaravone against PrP106-126-induced PC12 cell death.
2010 Jul-Aug
Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.
2010 Mar
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
2010 Mar 25
[Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].
2011 Jan
Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?
2011 Jan
Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.
2014 Jul
Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice.
2014 Oct
A novel pyrazolone-based derivative induces apoptosis in human esophageal cells via reactive oxygen species (ROS) generation and caspase-dependent mitochondria-mediated pathway.
2015 Apr 25
Change in soluble epoxide hydrolase (sEH) during cisplatin-induced acute renal failure in mice.
2015 Aug
Ginsenoside Rd attenuates Aβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons.
2015 Sep 5
Patents

Patents

4207317
1
JP2004307364A
1
JP2005029573A
1
JP2011062529A
1
JPH03215426A
1

Sample Use Guides

In Vivo Use Guide
30 mg of edaravone diluted with an appropriate volume of physiological saline, intravenously over 30 minutes twice a day in the morning and the evening (stroke); 60 mg of edaravone diluted with an appropriate volume of physiological saline, intravenously over 60 minutes once a day (amyotrophic lateral sclerosis).
Route of Administration: Intravenous
In Vitro Use Guide
1 uM or more of edaravone inhibited cultured vascular endothelial cell injury in vitro caused by 15-HPETE (hydroperoxyeicosatetraenoic acid).
Name Type Language
EDARAVONE
HSDB   INN   JAN   MART.   USAN   WHO-DD  
USAN   INN  
Official Name English
3H-PYRAZOL-3-ONE, 2,4-DIHYDRO-5-METHYL-2-PHENYL-
Systematic Name English
COLOREX PMP
Brand Name English
ANTIPYRINE RELATED COMPOUND A
USP-RS  
Common Name English
NORPHENAZONE [MI]
Common Name English
NSC-12
Code English
NSC-2629
Code English
C.I. DEVELOPER 1
Common Name English
NORPHENAZONE
MI  
Common Name English
DEVELOPER Z
Common Name English
RADICUT
Brand Name English
EDARAVONE [USAN]
Common Name English
EDARAVONE [HSDB]
Common Name English
EDARAVONE [WHO-DD]
Common Name English
MCI-186
Code English
1-PHENYL-3-METHYL-5-PYRAZOLONE
Systematic Name English
RADICAVA
Brand Name English
NSC-26139
Code English
JAROCOL PMP
Brand Name English
3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
Systematic Name English
PHENYL METHYL PYRAZOLONE
INCI  
INCI  
Official Name English
ANTIPYRINE RELATED COMPOUND A [USP-RS]
Common Name English
EDARAVONE [MART.]
Common Name English
EDARAVONE [JAN]
Common Name English
PHENYLMETHYLPYRAZOLONE
Systematic Name English
PHENYL METHYL PYRAZOLONE [INCI]
Common Name English
EDARAVONE [INN]
Common Name English
Code System Code Type Description
JAPANESE REVIEW
RADICUT
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY APPROVED JUNE 2015
RXCUI
1921877
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
CAS
89-25-8
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
MESH
C005435
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ChEMBL
CHEMBL290916
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
PUBCHEM
4021
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY SWITZERF
CAS
942-32-5
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
ALTERNATIVE
HSDB
89-25-8
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
WIKIPEDIA
EDARAVONE
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ECHA (EC/EINECS)
201-891-0
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
INN
7362
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
EVMPD
SUB06453MIG
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
MERCK INDEX
M8072
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
213-390-4
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
ALTERNATIVE
NCI_THESAURUS
C74323
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
EPA CompTox
942-32-5
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ACTIVE MOIETY
Structure of EDARAVONE
METABOLITE INACTIVE (PARENT)
Structure of EDARAVONE SULFATE
METABOLITE INACTIVE (PARENT)
Structure of EDARAVONE GLUCURONIDE
NIH
NCATS
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ACCESSIBILITY
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