U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C22H24Cl2N2O5
Molecular Weight 467.342
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PF-06821497

SMILES

CO[C@H](C1COC1)C2=C(Cl)C3=C(CCN(CC4=C(OC)C=C(C)NC4=O)C3=O)C(Cl)=C2

InChI

InChIKey=RXCVUHMIWHRLDF-HXUWFJFHSA-N
InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q15910|||Q96FI6
Gene ID: 2146.0
Gene Symbol: EZH2
Target Organism: Homo sapiens (Human)
Name Type Language
PF-06821497
Code English
1(2H)-ISOQUINOLINONE, 5,8-DICHLORO-2-((1,2-DIHYDRO-4-METHOXY-6-METHYL-2-OXO-3-PYRIDINYL)METHYL)-3,4-DIHYDRO-7-((R)-METHOXY-3-OXETANYLMETHYL)-
Common Name English
Code System Code Type Description
FDA UNII
S4L4MM20B6
Created by admin on Sat Dec 16 14:20:58 GMT 2023 , Edited by admin on Sat Dec 16 14:20:58 GMT 2023
PRIMARY
PUBCHEM
118572065
Created by admin on Sat Dec 16 14:20:58 GMT 2023 , Edited by admin on Sat Dec 16 14:20:58 GMT 2023
PRIMARY
CAS
1844849-10-0
Created by admin on Sat Dec 16 14:20:58 GMT 2023 , Edited by admin on Sat Dec 16 14:20:58 GMT 2023
PRIMARY
NCI_THESAURUS
C156743
Created by admin on Sat Dec 16 14:20:58 GMT 2023 , Edited by admin on Sat Dec 16 14:20:58 GMT 2023
PRIMARY
SMS_ID
300000041366
Created by admin on Sat Dec 16 14:20:58 GMT 2023 , Edited by admin on Sat Dec 16 14:20:58 GMT 2023
PRIMARY
DRUG BANK
DB14799
Created by admin on Sat Dec 16 14:20:58 GMT 2023 , Edited by admin on Sat Dec 16 14:20:58 GMT 2023
PRIMARY