LETIMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H18N2O3
Molecular Weight	262.3043
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCN1C(=O)OC2=C(C=CC=C2)C1=O

InChI

InChIKey=GRPWANKDBCDDEV-UHFFFAOYSA-N

InChI=1S/C14H18N2O3/c1-3-15(4-2)9-10-16-13(17)11-7-5-6-8-12(11)19-14(16)18/h5-8H,3-4,9-10H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2017789 | https://www.ncbi.nlm.nih.gov/pubmed/2017790 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 728, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Letimide is a new analgesic. It is a cyclic derivative of a salicylamide. The analgesic effect of this drug as determined in rats showed a higher potency than aspirin, but was without anti-inflammatory and antipyretic activity. Letimide is not a genotoxic agent according to the cytogenetic damage observed in vivo and in vitro, and would seem to justify other preclinical and clinical studies to confirm its lack of toxicity. Known adverse effects are headache and dizziness.

Approval Year

PubMed

Title	Date	PubMed
Genotoxic evaluation of letimide with the mouse bone marrow micronucleus test.	1991-04	2017789
Cytogenetic and teratogenic evaluation of letimide.	1991-04	2017790

Sample Use Guides

In Vivo Use Guide

30, 50 and 100 mg/kg

Route of Administration: Oral

Name

Type

Language

3-(2-DIETHYLAMINOETHYL)-2H-1,3-BENZOXAZINE-2-4(H)-DIONE

Preferred Name

English

LETIMIDE

Official Name

English

letimide [INN]

Common Name

English

2H-1,3-BENZOXAZINE-2,4(3H)-DIONE, 3-(2-(DIETHYLAMINO)ETHYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241