LETIMIDE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H18N2O3.ClH
Molecular Weight	298.765
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CC)CCN1C(=O)OC2=C(C=CC=C2)C1=O

InChI

InChIKey=QPFDPUCWRFYCFB-UHFFFAOYSA-N

InChI=1S/C14H18N2O3.ClH/c1-3-15(4-2)9-10-16-13(17)11-7-5-6-8-12(11)19-14(16)18;/h5-8H,3-4,9-10H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	C14H18N2O3
Molecular Weight	262.3043
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2017789 | https://www.ncbi.nlm.nih.gov/pubmed/2017790 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 728, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Letimide is a new analgesic. It is a cyclic derivative of a salicylamide. The analgesic effect of this drug as determined in rats showed a higher potency than aspirin, but was without anti-inflammatory and antipyretic activity. Letimide is not a genotoxic agent according to the cytogenetic damage observed in vivo and in vitro, and would seem to justify other preclinical and clinical studies to confirm its lack of toxicity. Known adverse effects are headache and dizziness.

Approval Year

PubMed

Title	Date	PubMed
Genotoxic evaluation of letimide with the mouse bone marrow micronucleus test.	1991 Apr	2017789
Cytogenetic and teratogenic evaluation of letimide.	1991 Apr	2017790

Sample Use Guides

In Vivo Use Guide

30, 50 and 100 mg/kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:45:29 GMT 2023` Edited by `admin` on `Fri Dec 15 18:45:29 GMT 2023`
Record UNII	VDU2239C1V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LETIMIDE HYDROCHLORIDE

Official Name

English

MA-1443

Code

English

LETIMIDE HYDROCHLORIDE [USAN]

Common Name

English

3-[2-(Diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione monohydrochloride

Systematic Name

English

2H-1,3-BENZOXAZINE-2,4(3H)-DIONE, 3-(2-(DIETHYLAMINO)ETHYL)-, MONOHYDROCHLORIDE

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C170112