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Details

Stereochemistry ACHIRAL
Molecular Formula C14H18N2O3.ClH
Molecular Weight 298.765
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LETIMIDE HYDROCHLORIDE

SMILES

Cl.CCN(CC)CCN1C(=O)OC2=C(C=CC=C2)C1=O

InChI

InChIKey=QPFDPUCWRFYCFB-UHFFFAOYSA-N
InChI=1S/C14H18N2O3.ClH/c1-3-15(4-2)9-10-16-13(17)11-7-5-6-8-12(11)19-14(16)18;/h5-8H,3-4,9-10H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula C14H18N2O3
Molecular Weight 262.3043
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Letimide is a new analgesic. It is a cyclic derivative of a salicylamide. The analgesic effect of this drug as determined in rats showed a higher potency than aspirin, but was without anti-inflammatory and antipyretic activity. Letimide is not a genotoxic agent according to the cytogenetic damage observed in vivo and in vitro, and would seem to justify other preclinical and clinical studies to confirm its lack of toxicity. Known adverse effects are headache and dizziness.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
30, 50 and 100 mg/kg
Route of Administration: Oral
Substance Class Chemical
Record UNII
VDU2239C1V
Record Status Validated (UNII)
Record Version