Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C5H8O5 |
| Molecular Weight | 148.114 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(CCC(O)=O)C(O)=O
InChI
InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N
InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: O75164 Gene ID: 9682.0 Gene Symbol: KDM4A Target Organism: Homo sapiens (Human) |
79.0 µM [IC50] | ||
Target ID: CHEMBL1938210 |
48.0 µM [IC50] | ||
Target ID: Q6NS38 Gene ID: 121642.0 Gene Symbol: ALKBH2 Target Organism: Homo sapiens (Human) |
150.0 µM [IC50] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells. | 2020-03 |
|
| Magnetic Resonance Spectroscopic Assessment of Isocitrate Dehydrogenase Status in Gliomas: The New Frontiers of Spectrobiopsy in Neurodiagnostics. | 2020-01 |
|
| To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 (IDH1) and 2-Hydroxy Glutarate (2-HG) in Gliomagenesis and Treatment Outcome in Glioma. | 2020-01 |
|
| Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration. | 2019-12-01 |
|
| I-8, a novel inhibitor of mutant IDH1, inhibits cancer progression in vitro and in vivo. | 2019-12-01 |
|
| Friend or foe-IDH1 mutations in glioma 10 years on. | 2019-11-25 |
|
| Metabolic profiling of human gliomas assessed with NMR. | 2019-10 |
|
| Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma. | 2019-10 |
|
| Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions. | 2019-09-07 |
|
| Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry. | 2019-08-02 |
|
| IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome. | 2019 |
|
| Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry. | 2019 |
|
| The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. | 2011-05 |
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| Code System | Code | Type | Description | ||
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alpha-Hydroxyglutaric acid
Created by
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DTXSID40864360
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RS4M3UYS95
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17084
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43
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2889-31-8
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admin on Wed Apr 02 10:05:33 GMT 2025 , Edited by admin on Wed Apr 02 10:05:33 GMT 2025
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SUBSTANCE RECORD
