2-HYDROXYGLUTARIC ACID, (±)-

OC(CCC(O)=O)C(O)=O

InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N

InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)

Targets

Primary Target	Pharmacology	Potency
Lysine-specific demethylase 4A 2 Target ID: O75164 Gene ID: 9682.0 Gene Symbol: KDM4A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21460794	Inhibitor 8297	79.0 µM [IC50]
Lysine-specific demethylase 2A 3 Target ID: CHEMBL1938210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21460794	Inhibitor 8297	48.0 µM [IC50]
DNA oxidative demethylase ALKBH2 1 Target ID: Q6NS38 Gene ID: 121642.0 Gene Symbol: ALKBH2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21460794	Inhibitor 8297	150.0 µM [IC50]

PubMed

Title	Date	PubMed
Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry.	2019 Aug 2	31375752
Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration.	2019 Dec 1	31561044
I-8, a novel inhibitor of mutant IDH1, inhibits cancer progression in vitro and in vivo.	2019 Dec 1	31518680

Name

Type

Language

2-HYDROXYGLUTARIC ACID, (±)-

Systematic Name

English

PENTANEDIOIC ACID, 2-HYDROXY-

Systematic Name

English

2,3-DIDEOXYPENTARIC ACID

Systematic Name

English

ALPHA-HYDROXYGLUTARIC ACID

Common Name

English

GLUTARIC ACID, 2-HYDROXY-

Systematic Name

English

2-HYDROXYPENTANEDIOIC ACID

Systematic Name

English

(±)-2-HYDROXYGLUTARIC ACID

Systematic Name

English

DL-2-HYDROXYGLUTARIC ACID

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

alpha-Hydroxyglutaric acid