Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C5H8O5 |
| Molecular Weight | 148.114 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(CCC(O)=O)C(O)=O
InChI
InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N
InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)
| Molecular Formula | C5H8O5 |
| Molecular Weight | 148.114 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: O75164 Gene ID: 9682.0 Gene Symbol: KDM4A Target Organism: Homo sapiens (Human) |
79.0 µM [IC50] | ||
Target ID: CHEMBL1938210 |
48.0 µM [IC50] | ||
Target ID: Q6NS38 Gene ID: 121642.0 Gene Symbol: ALKBH2 Target Organism: Homo sapiens (Human) |
150.0 µM [IC50] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome. | 2019 |
|
| Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry. | 2019 |
|
| Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration. | 2019 Dec 1 |
|
| I-8, a novel inhibitor of mutant IDH1, inhibits cancer progression in vitro and in vivo. | 2019 Dec 1 |
|
| Friend or foe-IDH1 mutations in glioma 10 years on. | 2019 Nov 25 |
|
| Metabolic profiling of human gliomas assessed with NMR. | 2019 Oct |
|
| Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions. | 2019 Sep 7 |
|
| To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 (IDH1) and 2-Hydroxy Glutarate (2-HG) in Gliomagenesis and Treatment Outcome in Glioma. | 2020 Jan |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:06:03 GMT 2023
by
admin
on
Sat Dec 16 18:06:03 GMT 2023
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| Record UNII |
RS4M3UYS95
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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alpha-Hydroxyglutaric acid
Created by
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DTXSID40864360
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RS4M3UYS95
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17084
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43
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2889-31-8
Created by
admin on Sat Dec 16 18:06:03 GMT 2023 , Edited by admin on Sat Dec 16 18:06:03 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ENANTIOMER -> RACEMATE |
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ENANTIOMER -> RACEMATE |
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