Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H20O11 |
| Molecular Weight | 448.3769 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(\C=C\C(=O)O[C@H](C(O)=O)[C@](O)(CC2=CC=C(O)C(O)=C2)C(O)=O)C=C1O
InChI
InChIKey=YVHLLZXSGPDXOA-ZHBFVYIWSA-N
InChI=1S/C21H20O11/c1-31-16-6-3-11(8-15(16)24)4-7-17(25)32-18(19(26)27)21(30,20(28)29)10-12-2-5-13(22)14(23)9-12/h2-9,18,22-24,30H,10H2,1H3,(H,26,27)(H,28,29)/b7-4+/t18-,21-/m1/s1
The potential effect of Cimicifugic acid B has being shown in preventing collagen degradation by collagenases or collagenolytic enzymes under pathological conditions, wound healing, or inflammation. Cimicifugic acid B inhibited neutrophil elastase with an IC50 of 11.4 umol/L. Cimicifugic acid B also inhibited HCT116 colon cancer cell growth.
Approval Year
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Cimicifuga racemosa (black cohosh) contains cimicifugic acid B.
Menopause Support: There is no proven effective dose for black cohosh. The British Herbal Compendium recommends 40-200 milligrams of dried rhizome daily in divided doses, although traditional doses have been as high as 1-2 grams three times daily.
Route of Administration:
Oral
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6449880
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admin on Fri Dec 15 22:05:50 GMT 2023 , Edited by admin on Fri Dec 15 22:05:50 GMT 2023
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205114-66-5
Created by
admin on Fri Dec 15 22:05:50 GMT 2023 , Edited by admin on Fri Dec 15 22:05:50 GMT 2023
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RMQ0SKL6CI
Created by
admin on Fri Dec 15 22:05:50 GMT 2023 , Edited by admin on Fri Dec 15 22:05:50 GMT 2023
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SUBSTANCE RECORD
