Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H17N3 |
| Molecular Weight | 155.2407 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN=C=NCCCN(C)C
InChI
InChIKey=LMDZBCPBFSXMTL-UHFFFAOYSA-N
InChI=1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3
1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) is a water-soluble carbodiimide. EDC is commonly used for the peptide synthesis, protein crosslinking to nucleic acids, preparation of immunoconjugates. EDC is also used in combination with N-hydroxysuccinimide (NHS) for the immobilisation of large biomolecules.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Proteomic profiling of platelet proteins by trypsin immobilized self-assembled monolayers digestion chip and protein identification using electrospray ionization tandem mass spectrometry. | 2004-10-01 |
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| Oligomeric state of the Escherichia coli metal transporter YiiP. | 2004-09-17 |
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| Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation. | 2004-07-15 |
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| Solid-supported solution-phase synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones. | 2004-07-13 |
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| Three-dimensional organization of the archaeal A1-ATPase from Methanosarcina mazei Gö1. | 2004-05-21 |
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| Cross-linking phosphatidylinositol-specific phospholipase C traps two activating phosphatidylcholine molecules on the enzyme. | 2004-05-07 |
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| Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol. | 2004-04-21 |
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| Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain. | 2004-04-16 |
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| Functional evaluation of collagen fiber scaffolds for ACL reconstruction: cyclic loading in proteolytic enzyme solutions. | 2004-04-01 |
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| Calcium dynamics of cortical astrocytic networks in vivo. | 2004-04 |
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| Subunit proximity in the H+-translocating NADH-quinone oxidoreductase probed by zero-length cross-linking. | 2004-03-30 |
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| On-line determination of carboxylic acids, aldehydes and ketones by high-performance liquid chromatography-diode array detection-atmospheric pressure chemical ionisation mass spectrometry after derivatization with 2-nitrophenylhydrazine. | 2004-03-26 |
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| Development of a direct-binding chloramphenicol sensor based on thiol or sulfide mediated self-assembled antibody monolayers. | 2004-02-15 |
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| Purification and characterization of ascorbic acid 2-kinase from Flavobacterium devorans ATCC 10829. | 2004-02 |
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| Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development. | 2004-02 |
|
| Biocompatibility and biodegradation of cross-linked gelatin/hyaluronic acid sponge in rat subcutaneous tissue. | 2004 |
|
| Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry. | 2003-12-16 |
|
| The study of the sterilization effect of gamma ray irradiation of immobilized collagen polypropylene nonwoven fabric surfaces. | 2003-12-01 |
|
| Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein. | 2003-12 |
|
| Endosomal proteolysis of glucagon at neutral pH generates the bioactive degradation product miniglucagon-(19-29). | 2003-12 |
|
| Polyacetal-doxorubicin conjugates designed for pH-dependent degradation. | 2003-11-20 |
|
| Electrogenerated chemiluminescence. 72. Determination of immobilized DNA and C-reactive protein on Au(111) electrodes using tris(2,2'-bipyridyl)ruthenium(II) labels. | 2003-11-01 |
|
| Covalent immobilization of chitosan and heparin on PLGA surface. | 2003-11 |
|
| Biomimetic surface modification of poly (L-lactic acid) with gelatin and its effects on articular chondrocytes in vitro. | 2003-09-15 |
|
| Enhancement effect of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and cationic surfactant on the chemiluminescence of poly(3, 4, 5-trihydroxybenzoate ester)dendrimers. | 2003-09-02 |
|
| Surface functionalization and grafting of heparin and/or RGD by an aqueous-based process to a poly(carbonate-urea)urethane cardiovascular graft for cellular engineering applications. | 2003-09-01 |
|
| Biomimetic surface modification of poly(L-lactic acid) with chitosan and its effects on articular chondrocytes in vitro. | 2003-09 |
|
| New cationized LDL-DNA complexes: their targeted delivery to fibroblasts in culture. | 2003-08-29 |
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| Liquid chromatographic determination of dicarboxylic acids based on intramolecular excimer-forming fluorescence derivatization. | 2003-08-22 |
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| Crosslinked collagen/chitosan matrix for artificial livers. | 2003-08 |
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| Release of ciprofloxacin from poloxamer-graft-hyaluronic acid hydrogels in vitro. | 2003-07-09 |
|
| Horseradish peroxidase immobilized through its carboxylic groups onto a polyacrylonitrile membrane: comparison of enzyme performances with inorganic beaded supports. | 2003-07 |
|
| Galactose-substituted alginate: preliminary characterization and study of gelling properties. | 2003-05-14 |
|
| Immunosensor for detection of Legionella pneumophila using surface plasmon resonance. | 2003-05 |
|
| Isolation of chromosaponin I-specific antibody by affinity chromatography. | 2003-03-14 |
|
| Biotinylation in the hyperthermophile Aquifex aeolicus. | 2003-03 |
|
| Carboxylate groups on the manganese-stabilizing protein are required for efficient binding of the 24 kDa extrinsic protein to photosystem II. | 2003-02-25 |
|
| Protein immobilization on plasma-polymerized ethylenediamine-coated glass slides. | 2003-02-01 |
|
| The influence of glycosaminoglycans and crosslinking agents on the phenotype of hepatocytes cultured on collagen gels. | 2003-02 |
|
| Functional stabilization of trypsin by conjugation with beta-cyclodextrin-modified carboxymethylcellulose. | 2003-02 |
|
| Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. | 2003-01-02 |
|
| Identification of functionally important acidic residues in transducin by group-specific labeling. | 2003 |
|
| Biochemical and structural characterization of the cross-linked complex of nitrogenase: comparison to the ADP-AlF4(-)-stabilized structure. | 2002-12-31 |
|
| Further stabilization of earthworm serine protease by chemical modification and immobilization. | 2002-12 |
|
| Polymerized degradable hyaluronan--a platform for stent coating with inherent inhibitory effects on neointimal formation in a porcine coronary model. | 2002-12 |
|
| Kinetic studies on the rate of hydrolysis of N-ethyl-N'-(dimethylaminopropyl)carbodiimide in aqueous solutions using mass spectrometry and capillary electrophoresis. | 2002-11-01 |
|
| Analysis of aminofluorescein-fatty acid derivatives by capillary electrophoresis with laser-induced fluorescence detection at the attomole level: application to mycobacterial fatty acids. | 2002-10-11 |
|
| Cytotoxicity evaluation of gelatin sponges prepared with different cross-linking agents. | 2002 |
|
| The influence of crosslinking agents and diamines on the pore size, morphology and the biological stability of collagen sponges and their effect on cell penetration through the sponge matrix. | 2001-09 |
|
| Cross-linking by 1-ethyl-3- (3-dimethylaminopropyl)-carbodiimide (EDC) of a collagen/elastin membrane meant to be used as a dermal substitute: effects on physical, biochemical and biological features in vitro. | 2001-05 |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: Reaction of the ATPase of Escherichia coli (ECF1) with 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) resulted in a time- and concentration-dependent inhibition of ATPase activity.
Close to 13 mol of EDC per mol of ECF1 was incorporated into the enzyme at 95% inhibition of ATPase activity. Two-thirds of the label was found to be associated with subunit beta with a stoichiometry of about 3 mol of EDC per mol of beta.
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217-579-2
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1892-57-5
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15908
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DTXSID60865258
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RJ5OZG6I4A
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300000011101
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1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
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m4825
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SUBSTANCE RECORD
