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Details

Stereochemistry ACHIRAL
Molecular Formula C8H17N3
Molecular Weight 155.2407
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of 1-ETHYL-3-(3-(DIMETHYLAMINO)PROPYL)CARBODIIMIDE

SMILES

CCN=C=NCCCN(C)C

InChI

InChIKey=LMDZBCPBFSXMTL-UHFFFAOYSA-N
InChI=1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3

HIDE SMILES / InChI
Molecular Formula C8H17N3
Molecular Weight 155.2407
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 2
Optical Activity NONE

Description

1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) is a water-soluble carbodiimide. EDC is commonly used for the peptide synthesis, protein crosslinking to nucleic acids, preparation of immunoconjugates. EDC is also used in combination with N-hydroxysuccinimide (NHS) for the immobilisation of large biomolecules.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Control of pH alters the type of cross-linking produced by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) treatment of acellular matrix vascular grafts.
2001
Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology.
2001 Apr 15
Conjugation of monoclonal antibodies with TETA using activated esters: biological comparison of 64Cu-TETA-1A3 with 64Cu-BAT-2IT-1A3.
2001 Dec
Optimizing the immobilization of single-stranded DNA onto glass beads.
2001 Feb 26
Formulation and release characteristics of poly(lactic-co-glycolic acid) microspheres containing chemically modified protein.
2001 Jan
Electrochemical detection of sequence-specific DNA using a DNA probe labeled with aminoferrocene and chitosan modified electrode immobilized with ssDNA.
2001 Jan
The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates.
2001 Jan
Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa.
2001 Jul
Cooperativity and substrate specificity of an alkaline amylase and neopullulanase complex of Micrococcus halobius OR-1.
2001 Mar
Functional role of the C-terminal domain of smooth muscle myosin light chain kinase on the phosphorylation of smooth muscle myosin.
2001 Mar
Interaction of the N-terminal part of the A1 essential light chain with the myosin heavy chain.
2001 Mar 9
Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N.
2001 Nov
Synthesis and characterization of a novel glycopolymer with protective activity toward human anti-alpha-Gal antibodies.
2002 Apr
Further stabilization of earthworm serine protease by chemical modification and immobilization.
2002 Dec
Polymerized degradable hyaluronan--a platform for stent coating with inherent inhibitory effects on neointimal formation in a porcine coronary model.
2002 Dec
Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linking.
2002 Feb
Novel functional biodegradable polymer: synthesis and anticoagulant activity of poly(gamma-glutamic acid)sulfonate (gamma-PGA-sulfonate).
2002 Jan-Feb
Self-contained microelectrochemical immunoassay for small volumes using mouse IgG as a model system.
2002 Jul 15
Development of 7-(N,N-dimethylaminosulfonyl)-5-N-(4-N-aminoethyl)piperazino-2,1,3-benzoxadiazole as a water-soluble fluorogenic reagent for the sensitive liquid chromatographic determination of saturated carboxylic acids.
2002 Jun
A cross-linked profilin-actin heterodimer interferes with elongation at the fast-growing end of F-actin.
2002 May 3
Preparation and biocompatibility of tissue-engineered scaffold materials based on collagen.
2002 Oct
Identification of functionally important acidic residues in transducin by group-specific labeling.
2003
Functional stabilization of trypsin by conjugation with beta-cyclodextrin-modified carboxymethylcellulose.
2003 Feb
Carboxylate groups on the manganese-stabilizing protein are required for efficient binding of the 24 kDa extrinsic protein to photosystem II.
2003 Feb 25
Enhancement effect of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and cationic surfactant on the chemiluminescence of poly(3, 4, 5-trihydroxybenzoate ester)dendrimers.
2003 Jul-Aug
New cationized LDL-DNA complexes: their targeted delivery to fibroblasts in culture.
2003 Jul-Sep
Polyacetal-doxorubicin conjugates designed for pH-dependent degradation.
2003 Nov-Dec
Calcium dynamics of cortical astrocytic networks in vivo.
2004 Apr
Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain.
2004 Apr 16
Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol.
2004 Apr 21
Purification and characterization of ascorbic acid 2-kinase from Flavobacterium devorans ATCC 10829.
2004 Feb
Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development.
2004 Feb
Development of a direct-binding chloramphenicol sensor based on thiol or sulfide mediated self-assembled antibody monolayers.
2004 Feb 15
On-line determination of carboxylic acids, aldehydes and ketones by high-performance liquid chromatography-diode array detection-atmospheric pressure chemical ionisation mass spectrometry after derivatization with 2-nitrophenylhydrazine.
2004 Mar 26
Subunit proximity in the H+-translocating NADH-quinone oxidoreductase probed by zero-length cross-linking.
2004 Mar 30
Proteomic profiling of platelet proteins by trypsin immobilized self-assembled monolayers digestion chip and protein identification using electrospray ionization tandem mass spectrometry.
2004 Oct 1
Patents

Patents

05055451
2
05278316
4
05344830
2
05459151
6
05550131
2
05563162
3
05574042
2
05622983
4
05659044
6
05670503
2
05696270
7
05773428
4
05847155
4
05948777
2
JP1052796A
2
JP2000143599A
2
JP2000351792A
2
JP2001081104A
4
JP2001261624A
3
JP2002503456A
2
JP2003505672A
2
JP2005112951A
2
JP2005179288A
2
JP2007500043A
2
JP2008292440A
2
JP2008540726A
2
JP2009128297A
2
JP2009285155A
2
JP2009515569A
2
JP2010202544A
2
JP2010511744A
5
JP2010515762A
2
JP2010526159A
2
JP2011507609A
2
JP2011521898A
2
JP2011524398A
2
JP2011525182A
4
JP3765828B2
2
JP4769257B2
16
JPH01119261A
2
JPH01224662A
2
JPH01224663A
2
JPH01226854A
4
JPH02145600A
3
JPH02275900A
2
JPH0262889A
2
JPH0363299A
2
JPH04108377A
2
JPH04126074A
2
JPH04182499A
2
JPH04325099A
2
JPH04327592A
2
JPH04364200A
2
JPH0469384A
2
JPH06172387A
2
JPH07285951A
2
JPH0790080A
2
JPH08119940A
2
JPH08193096A
2
JPH08217751A
2
JPH08325160A
2
JPH09110818A
2
JPH09221454A
2
JPH09257799A
2
JPH09296039A
2
JPH0948750A
2
JPH11147839A
2
JPH11180950A
2
JPH11193273A
2
JPS06452796A
2
JPS0667502A
2
JPS5599072A
2
JPS5614944A
2

Sample Use Guides

In Vitro Use Guide
Curator's Comment: Reaction of the ATPase of Escherichia coli (ECF1) with 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) resulted in a time- and concentration-dependent inhibition of ATPase activity.
Close to 13 mol of EDC per mol of ECF1 was incorporated into the enzyme at 95% inhibition of ATPase activity. Two-thirds of the label was found to be associated with subunit beta with a stoichiometry of about 3 mol of EDC per mol of beta.
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:50:43 GMT 2023
Edited
by admin
on Fri Dec 15 18:50:43 GMT 2023
Record UNII
RJ5OZG6I4A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1-ETHYL-3-(3-(DIMETHYLAMINO)PROPYL)CARBODIIMIDE
Systematic Name English
EDAC
Common Name English
N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE
Systematic Name English
N3-(ETHYLCARBONIMIDOYL)-N1,N1-DIMETHYL-1,3-PROPANEDIAMINE
Systematic Name English
1-ETHYL-3-(DIMETHYLAMINOPROPYL)CARBODIIMIDE
Systematic Name English
ETHYLDIMETHYLAMINOPROPYL CARBODIIMIDE
Systematic Name English
EDC [MI]
Common Name English
N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE
Systematic Name English
1-ETHYL-3-(3'-DIMETHYLAMINOPROPYL)CARBODIIMIDE
Common Name English
ETHYL-DI(METHYLAMINO)-2-PROPYLCARBONDIIMIDE, 1-
Common Name English
EDCI
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
217-579-2
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
CAS
1892-57-5
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
PUBCHEM
15908
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
EPA CompTox
DTXSID60865258
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
FDA UNII
RJ5OZG6I4A
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
SMS_ID
300000011101
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
WIKIPEDIA
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY
MERCK INDEX
m4825
Created by admin on Fri Dec 15 18:50:43 GMT 2023 , Edited by admin on Fri Dec 15 18:50:43 GMT 2023
PRIMARY Merck Index
NIH
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