CARNIDAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H12N4O3S
Molecular Weight	244.271
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=S)NCCN1C(C)=NC=C1[N+]([O-])=O

InChI

InChIKey=OVEVHVURWWTPFC-UHFFFAOYSA-N

InChI=1S/C8H12N4O3S/c1-6-10-5-7(12(13)14)11(6)4-3-9-8(16)15-2/h5H,3-4H2,1-2H3,(H,9,16)

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/carnidazole.html

Carnidazole (trade name Spartrix) is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. Spartrix (Carnidazole) is indicated for oral treatment of trichomoniasis (canker) in ornamental and homing (non-food) pigeons.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Trichomonas 2 Target ID: CHEMBL613161 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9786623	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Vaginal trichomoniasis 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6995193 https://www.ncbi.nlm.nih.gov/pubmed/322823	Curative		Phase I 438	Unknown Approved Use Unknown
Trichomoniasis (canker) in ornamental and homing (non-food) pigeons 2 Sources: http://www.jedds.com/shop/spartrix-tablets-50-count/	Curative		Approved 8583	Spartrix Approved Use Spartrix (Carnidazole) is indicated for oral treatment of trichomoniasis (canker) in ornamental and homing (non-food) pigeons. Launch Date 1989

Doses

Dose	Population	Adverse events
2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	Other AEs: Nausea, Vomitin... Other AEs: Nausea (grade 1, 13%) Vomitin (grade 1, 5%) Diarrhea (grade 1, 1%) Dry mouth (grade 1, 1%) Dizziness (grade 1, 1%) Headache (grade 1, 1%) Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/

AEs

AE	Significance	Dose	Population
Diarrhea	grade 1, 1%	2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/
Dizziness	grade 1, 1%	2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/
Dry mouth	grade 1, 1%	2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/
Headache	grade 1, 1%	2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/
Nausea	grade 1, 13%	2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/
Vomitin	grade 1, 5%	2 g single, oral Highest studied dose Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6995193/

PubMed

Title	Date	PubMed
Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS).	2010-09	20597022
Rapid confirmatory method for the determination of 11 nitroimidazoles in egg using liquid chromatography tandem mass spectrometry.	2009-11-13	19446819
Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry.	2009-05-15	19345159
Crystal structure of carnidazole form II from synchrotron X-ray powder diffraction: structural comparison with form I, the hydrated form and the low energy conformations in vacuo.	2006-10	16892212
Antiprotozoals effective in vitro against the scuticociliate fish pathogen Philasterides dicentrarchi.	2002-06-03	12113305

Patents

Sample Use Guides

In Vivo Use Guide

Pigeons: 1 tablet per adult pigeon and half tablet per young pigeon. A single dose is usually sufficient. In cases where pigeon does not respond within 3 days, it may be treated again.

Route of Administration: Oral

In Vitro Use Guide

Carnidazole, dimetridazole, metronidazole and ornidazole showed a similar activity against isolates HF26, 79P and P2, with MLCs ranging from 1.9 to 7.8 ug/ml.

Name

Type

Language

CARNIDAZOLE

Official Name

English

NSC-293873

Preferred Name

English

R 28,096 FREE BASE

Code

English

CARNIDAZOLE [MART.]

Common Name

English

R-25831

Code

English

R 25,831

Code

English

CARBAMOTHIOIC ACID, (2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL)-, O-METHYL ESTER

Common Name

English

R-28096 FREE BASE

Code

English

CARNIDAZOLE [GREEN BOOK]

Common Name

English

carnidazole [INN]

Common Name

English

CARNIDAZOLE [MI]

Common Name

English

CARNIDAZOLE [USAN]

Common Name

English

O-Methyl [2-(2-methyl-5-nitroimidazol-1-yl)ethyl]thiocarbamate

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 520.302