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Details

Stereochemistry ACHIRAL
Molecular Formula C8H12N4O3S.ClH
Molecular Weight 280.732
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARNIDAZOLE HYDROCHLORIDE

SMILES

Cl.COC(=S)NCCN1C(C)=NC=C1[N+]([O-])=O

InChI

InChIKey=RIUCUZVIVKJIFC-UHFFFAOYSA-N
InChI=1S/C8H12N4O3S.ClH/c1-6-10-5-7(12(13)14)11(6)4-3-9-8(16)15-2;/h5H,3-4H2,1-2H3,(H,9,16);1H

HIDE SMILES / InChI
Molecular Formula C8H12N4O3S
Molecular Weight 244.271
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Carnidazole (trade name Spartrix) is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. Spartrix (Carnidazole) is indicated for oral treatment of trichomoniasis (canker) in ornamental and homing (non-food) pigeons.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Phase I
428
Unknown

Approved Use

Unknown
Curative
Approved
8429
Spartrix

Approved Use

Spartrix (Carnidazole) is indicated for oral treatment of trichomoniasis (canker) in ornamental and homing (non-food) pigeons.

Launch Date

6.1784641E11
PubMed

PubMed

TitleDatePubMed
Crystal structure of carnidazole form II from synchrotron X-ray powder diffraction: structural comparison with form I, the hydrated form and the low energy conformations in vacuo.
2006 Oct
Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry.
2009 May 15
Rapid confirmatory method for the determination of 11 nitroimidazoles in egg using liquid chromatography tandem mass spectrometry.
2009 Nov 13
Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS).
2010 Sep
Patents

Patents

US4837168
2
US5872013
2

Sample Use Guides

In Vivo Use Guide
Pigeons: 1 tablet per adult pigeon and half tablet per young pigeon. A single dose is usually sufficient. In cases where pigeon does not respond within 3 days, it may be treated again.
Route of Administration: Oral
In Vitro Use Guide
Carnidazole, dimetridazole, metronidazole and ornidazole showed a similar activity against isolates HF26, 79P and P2, with MLCs ranging from 1.9 to 7.8 ug/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 12:44:19 UTC 2023
Edited
by admin
on Sat Dec 16 12:44:19 UTC 2023
Record UNII
G0I5C2CC38
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CARNIDAZOLE HYDROCHLORIDE
Common Name English
R-28096
Code English
CARBAMOTHIOIC ACID, (2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL)-, O-METHYL ESTER, MONOHYDROCHLORIDE
Systematic Name English
R 28,096
Code English
Code System Code Type Description
FDA UNII
G0I5C2CC38
Created by admin on Sat Dec 16 12:44:19 UTC 2023 , Edited by admin on Sat Dec 16 12:44:19 UTC 2023
PRIMARY
PUBCHEM
123133457
Created by admin on Sat Dec 16 12:44:19 UTC 2023 , Edited by admin on Sat Dec 16 12:44:19 UTC 2023
PRIMARY
CAS
55455-75-9
Created by admin on Sat Dec 16 12:44:19 UTC 2023 , Edited by admin on Sat Dec 16 12:44:19 UTC 2023
PRIMARY
Related Record Type Details
Structure of CARNIDAZOLE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of CARNIDAZOLE
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