PENTIAPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N5S
Molecular Weight	299.394
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=NC=CN24

InChI

InChIKey=FACMWMBWGSPRKO-UHFFFAOYSA-N

InChI=1S/C15H17N5S/c1-18-8-10-19(11-9-18)14-17-12-4-2-3-5-13(12)21-15-16-6-7-20(14)15/h2-7H,8-11H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11704248 | https://www.ncbi.nlm.nih.gov/pubmed/9443558 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 948, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Pentiapine is a dopamine release inhibitor. It is a tranquiliser. Pentiapine produces a dose-dependent decrease in spontaneous motor activity and blocks the morphineinduced hyperactivity. Moreover, this drug in itself has no effect on place conditioning but blocks the acquisition of morphine-induced conditioned place preference.

Approval Year

PubMed

Title	Date	PubMed
Effects of CGS 10746B on hyperactivity and place preference induced by morphine.	2001-11-29	11704248
CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences.	1998-01	9443558

Patents

Sample Use Guides

In Vivo Use Guide

24 and 32 mg/kg

Route of Administration: Intraperitoneal

Name

Type

Language

pentiapine [INN]

Preferred Name

English

PENTIAPINE

Official Name

English

5-(4-METHYL-1-PIPERAZINYL)IMIDAZO(2,1-B)(1,3,5)BENZOTHIADIAZEPINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883