N-CYANO-N'-(1,1-DIMETHYL-PROPYL)-N''-3-PYRIDINYL GUANIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H17N5
Molecular Weight	231.2969
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of N-CYANO-N'-(1,1-DIMETHYL-PROPYL)-N''-3-PYRIDINYL GUANIDINE

Structure Search

SMILES

CCC(C)(C)NC(NC1=CC=CN=C1)=NC#N

InChI

InChIKey=HKZNADVVGXKQDL-UHFFFAOYSA-N

InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Sulfonylurea receptor 2, Kir6.2 11 Target ID: CHEMBL2095198 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17154517	Opener 34	21.88 nM [EC50]
Sulfonylurea receptor 2 9 Target ID: CHEMBL1971 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19101153	Opener 34	230.0 nM [EC50]
Sulfonylurea receptors; K-ATP channels 11 Target ID: CHEMBL2095152 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15163196\|https://www.ncbi.nlm.nih.gov/pubmed/10988346	Opener 34	21.88 nM [EC50]

PubMed

Title	Date	PubMed
Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes.	2001 Jul	11408614
PNU-83757: a new agent for the treatment of erectile dysfunction.	2002 Dec	12425868
Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.	2004 Apr	15023854
Lipids modulate ligand binding to sulphonylurea receptors.	2005 Aug	15895108
Alteration of binding sites for [3H]P1075 and [3H]glibenclamide in renovascular hypertensive rat aorta.	2005 Jan	15659117
Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell line.	2005 Jan	15613976
Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress.	2005 Oct	16099467
Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2.	2008 Jul 1	18450778
Potassium fluxes, energy metabolism, and oxygenation in intact diabetic rat hearts under normal and stress conditions.	2008 Oct	18841176
Substitution of the Walker A lysine by arginine in the nucleotide-binding domains of sulphonylurea receptor SUR2B: effects on ligand binding and channel activity.	2010 Jun	20352196

Name

Type

Language

N-CYANO-N'-(1,1-DIMETHYL-PROPYL)-N''-3-PYRIDINYL GUANIDINE

Systematic Name

English

P 1075

Code

English

U-83757

Code

English

P-1075

Code

English

PNU-83757

Code

English

GUANIDINE, N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDINYL-

Systematic Name

English

Code System Code Type Description

PUBCHEM

43345

Created by admin on Fri Dec 15 15:45:51 GMT 2023 , Edited by admin on Fri Dec 15 15:45:51 GMT 2023

PRIMARY

FDA UNII

RA77IZ6B2F

Created by admin on Fri Dec 15 15:45:51 GMT 2023 , Edited by admin on Fri Dec 15 15:45:51 GMT 2023

PRIMARY

CAS

60559-98-0

Created by admin on Fri Dec 15 15:45:51 GMT 2023 , Edited by admin on Fri Dec 15 15:45:51 GMT 2023

PRIMARY

EPA CompTox

DTXSID60209335

Created by admin on Fri Dec 15 15:45:51 GMT 2023 , Edited by admin on Fri Dec 15 15:45:51 GMT 2023

PRIMARY

ACTIVE MOIETY


					RA77IZ6B2F

N-CYANO-N'-(1,1-DIMETHYL-PROPYL)-N''-3-PYRIDINYL GUANIDINE