Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H17N5 |
| Molecular Weight | 231.2969 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C)(C)NC(NC1=CC=CN=C1)=NC#N
InChI
InChIKey=HKZNADVVGXKQDL-UHFFFAOYSA-N
InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes. | 2001 Jul |
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| Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes. | 2001 Jul-Aug |
|
| Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts. | 2002 Apr |
|
| The efficacy, safety and tolerability of intracavernous PNU-83757 for the treatment of erectile dysfunction. | 2002 Jun |
|
| Cardioselective sulfonylthiourea HMR 1098 blocks mitochondrial uncoupling induced by a KATP channel opener, P-1075, in beating rat hearts. | 2003 Jul 14 |
|
| Binding and effect of K ATP channel openers in the absence of Mg2+. | 2003 May |
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| P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. | 2003 Sep |
|
| Selective ATP-sensitive potassium channel openers: fact or fiction. | 2003 Sep |
|
| In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892. | 2004 Sep |
|
| Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels. | 2005 Jul |
|
| P-1075 exerts diverse modulatory effects on mitochondrial ATP-sensitive K+ channels in rabbit ventricular myocytes. | 2006 Feb |
|
| Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs. | 2006 Feb 17 |
|
| GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. | 2007 Jul |
|
| Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel. | 2008 Dec 1 |
|
| Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2. | 2008 Jul 1 |
|
| K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries. | 2008 May |
|
| Potassium fluxes, energy metabolism, and oxygenation in intact diabetic rat hearts under normal and stress conditions. | 2008 Oct |
|
| Substitution of the Walker A lysine by arginine in the nucleotide-binding domains of sulphonylurea receptor SUR2B: effects on ligand binding and channel activity. | 2010 Jun |
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43345
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RA77IZ6B2F
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60559-98-0
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DTXSID60209335
Created by
admin on Fri Dec 15 15:45:51 GMT 2023 , Edited by admin on Fri Dec 15 15:45:51 GMT 2023
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