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Details

Stereochemistry RACEMIC
Molecular Formula C14H21N3O3
Molecular Weight 279.3348
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CGP-12177, (±)-

SMILES

CC(C)(C)NCC(O)COC1=C2NC(=O)NC2=CC=C1

InChI

InChIKey=UMQUQWCJKFOUGV-UHFFFAOYSA-N
InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19)

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
9.21 null [pKd]
9.39 null [pKd]
6.99 null [pKd]
PubMed

PubMed

TitleDatePubMed
Is the "atypical" beta-receptor in the rat stomach fundus the rat beta 3 receptor?
1995 Jan
Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.
1996 Jan
Beta 3-adrenergic receptor-mediated lipolysis and oxygen consumption in brown adipocytes from cynomolgus monkeys.
1997 Feb
Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors.
1997 Jan
Functional, biochemical and molecular biological evidence for a possible beta(3)-adrenoceptor in human near-term myometrium.
2000 Aug
In vivo quantification and parametric images of the cardiac beta-adrenergic receptor density.
2002 Feb
Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor.
2003 Jun
Effects of growth hormone on the function of beta-adrenoceptor subtypes in rat adipocytes.
2004 Feb
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.
2005 Feb
Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis.
2005 Sep
In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor.
2007 Jun
Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human beta1-adrenoceptor.
2008 Nov
Name Type Language
CGP-12177, (±)-
Code English
(±)-CGP-12177
Code English
4-(3-(TERT-BUTYLAMINO)-2-HYDROXYPROPOXY)-1,3-DIHYDROBENZIMIDAZOL-2-ONE
Systematic Name English
2H-BENZIMIDAZOL-2-ONE, 4-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)-1,3-DIHYDRO-
Systematic Name English
CGP 12177
Code English
Code System Code Type Description
FDA UNII
R89UMZ82MJ
Created by admin on Sat Dec 16 08:23:54 UTC 2023 , Edited by admin on Sat Dec 16 08:23:54 UTC 2023
PRIMARY
EPA CompTox
DTXSID901001733
Created by admin on Sat Dec 16 08:23:54 UTC 2023 , Edited by admin on Sat Dec 16 08:23:54 UTC 2023
PRIMARY
PUBCHEM
2687
Created by admin on Sat Dec 16 08:23:54 UTC 2023 , Edited by admin on Sat Dec 16 08:23:54 UTC 2023
PRIMARY
CAS
81047-99-6
Created by admin on Sat Dec 16 08:23:54 UTC 2023 , Edited by admin on Sat Dec 16 08:23:54 UTC 2023
PRIMARY