Details
Stereochemistry | RACEMIC |
Molecular Formula | C14H21N3O3 |
Molecular Weight | 279.3348 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NCC(O)COC1=C2NC(=O)NC2=CC=C1
InChI
InChIKey=UMQUQWCJKFOUGV-UHFFFAOYSA-N
InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19)
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL213 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15655528 |
9.21 null [pKd] | ||
Target ID: CHEMBL210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15655528 |
9.39 null [pKd] | ||
Target ID: CHEMBL246 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15655528 |
6.99 null [pKd] |
PubMed
Title | Date | PubMed |
---|---|---|
Is the "atypical" beta-receptor in the rat stomach fundus the rat beta 3 receptor? | 1995 Jan |
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Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. | 1996 Jan |
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Beta 3-adrenergic receptor-mediated lipolysis and oxygen consumption in brown adipocytes from cynomolgus monkeys. | 1997 Feb |
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Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors. | 1997 Jan |
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Functional, biochemical and molecular biological evidence for a possible beta(3)-adrenoceptor in human near-term myometrium. | 2000 Aug |
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In vivo quantification and parametric images of the cardiac beta-adrenergic receptor density. | 2002 Feb |
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Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. | 2003 Jun |
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Effects of growth hormone on the function of beta-adrenoceptor subtypes in rat adipocytes. | 2004 Feb |
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The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. | 2005 Feb |
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Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis. | 2005 Sep |
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In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor. | 2007 Jun |
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Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human beta1-adrenoceptor. | 2008 Nov |
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R89UMZ82MJ
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DTXSID901001733
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2687
Created by
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81047-99-6
Created by
admin on Sat Dec 16 08:23:54 UTC 2023 , Edited by admin on Sat Dec 16 08:23:54 UTC 2023
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SUBSTANCE RECORD