PICLONIDINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H17Cl2N3O
Molecular Weight	314.21
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=CC(Cl)=C1N(C2CCCCO2)C3=NCCN3

InChI

InChIKey=NYQGJEQCYOJBPV-UHFFFAOYSA-N

InChI=1S/C14H17Cl2N3O/c15-10-4-3-5-11(16)13(10)19(14-17-7-8-18-14)12-6-1-2-9-20-12/h3-5,12H,1-2,6-9H2,(H,17,18)

HIDE SMILES / InChI

Description
Sources: https://apps.who.int/iris/bitstream/handle/10665/67830/WHO_EDM_QSM_2003.2.pdf | https://www.ncbi.nlm.nih.gov/pubmed/6111589 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 977, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piclonidine is imidazoline derivative. Piclonidine has a relative specificity for the hypotensive action and thus indicate that the compound differs from the chemical congener clonidine which has other pharmacological effects involving several peripheral or centrally regulated autonomic functions. Unlike clonidine, this chemically related compound did not evoke hypertensive episodes or cause sedation in animals up to the oral dose of 1 mg/kg.

Originator

Approval Year

PubMed

Title	Date	PubMed
New centrally acting antihypertensive drugs related to methyldopa and clonidine.	1984-09-01	6094350
Comparative pharmacological profile of two imidazoline derivatives endowed with strong hypotensive activity: LR 99853 and clonidine.	1981-02	6111589

Patents

Name

Type

Language

LR-99853

Preferred Name

English

PICLONIDINE

Official Name

English

N-(2,6-DICHLOROPHENYL)-4,5-DIHYDRO-N-(TETRAHYDRO-2H-PYRAN-2-YL)-1H-IMIDAZOL-2-AMINE

Common Name

English

LR99853

Code

English

piclonidine [INN]

Common Name

English

1H-IMIDAZOL-2-AMINE, N-(2,6-DICHLOROPHENYL)-4,5-DIHYDRO-N-(TETRAHYDRO-2H-PYRAN-2-YL)-

Systematic Name

English

(±)-2-(2,6-DICHLORO-N-(TETRAHYDRO-2H-PYRAN-2-YL)ANILINO-2-IMIDAZOLINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270