PHENYRAMIDOL

US Previously Marketed

First approved in 1960

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H14N2O
Molecular Weight	214.2631
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CNC1=CC=CC=N1)C2=CC=CC=C2

InChI

InChIKey=ZEAJXCPGHPJVNP-UHFFFAOYSA-N

InChI=1S/C13H14N2O/c16-12(11-6-2-1-3-7-11)10-15-13-8-4-5-9-14-13/h1-9,12,16H,10H2,(H,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14428054 | https://www.ncbi.nlm.nih.gov/pubmed/13797562 | https://www.ncbi.nlm.nih.gov/pubmed/12921508

PHENYRAMIDOL (ANALEXIN®), also known as fenyramidol, is an aminopyridine derivative, used as analgesic and muscle relaxant. It is considered as a drug that possibly causes hepatotoxicity.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13999595	Primary		Approved 8429	Analexin Approved Use Analgesic, Muscle relaxant Launch Date -3.15619213E11

Doses

Dose	Population	Adverse events
400 mg 2 times / day multiple, oral Dose: 400 mg, 2 times / day Route: oral Route: multiple Dose: 400 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/12921508	unhealthy, 70 years n = 1 Health Status: unhealthy Age Group: 70 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/12921508	Disc. AE: Liver injury... AEs leading to discontinuation/dose reduction: Liver injury Sources: https://pubmed.ncbi.nlm.nih.gov/12921508

AEs

AE	Significance	Dose	Population
Liver injury	Disc. AE	400 mg 2 times / day multiple, oral Dose: 400 mg, 2 times / day Route: oral Route: multiple Dose: 400 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/12921508	unhealthy, 70 years n = 1 Health Status: unhealthy Age Group: 70 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/12921508

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY548700	https://www.001chemical.com/chem/326-43-2
ABI Chem	AC1L1T44
Alfa Chemistry	ACM326432
BOC Sciences	326-43-2
BOC Sciences	553-69-5
Chemieliva Pharmaceutical Co., Ltd	PBCM0639514
Chemspace	CSC000251451
Chemspace	CSC010499475
Chemspace	CSC010556475
Compound Cloud	9469
Compound Cloud	9470
Enamine	BBV-24869013
Enamine	BBV-45306755
Enamine	BBV-45369977
Enamine	Z31268347
Finetech	FT-0699783	http://www.finetechnology-ind.com/prod/detail/pub/553-69-5.html
HongKong Chemhere	SCA18366
MolPort	MolPort-006-111-788
Molcore	MC548700	https://www.molcore.com/product/326-43-2
NCI Plated 2007	17777
NovoSeek	9470
Smolecule	S576140	https://www.smolecule.com/products/s576140
THE BioTek	bt-368553	https://www.thebiotek.com/product/others/bt-368553
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.	PH-2488AA
ZINC	ZINC000022910917	http://zinc15.docking.org/substances/ZINC000022910917
ZINC	ZINC000022910921	http://zinc15.docking.org/substances/ZINC000022910921
eMolecules	37191127
eMolecules	76759028
eNovation Chemicals	D140204
mcule	MCULE-9231150796	https://mcule.com/MCULE-9231150796/

PubMed

Title	Date	PubMed
Analgesic effectiveness of phenyramidol hydrochloride, a new aminopyridine derivative.	1959 Sep	13797562
Pharmacology of phenyramidol (IN511) with emphasis on analgesic and muscle-relaxant effects.	1960 Mar 30	14428054
Phenyramidol-associated liver toxicity.	2003 Sep	12921508

Patents

Name

Type

Language

PHENYRAMIDOL

Common Name

English

BENZYL ALCOHOL, .ALPHA.-((2-PYRIDYLAMINO)METHYL)-

Systematic Name

English

CABRAL

Common Name

English

MJ-505

Code

English

EVASPRIN

Common Name

English

NSC-23634

Code

English

FENYRAMIDOL

Official Name

English

fenyramidol [INN]

Common Name

English

(±)-PHENYRAMIDOL

Common Name

English

PHENYRAMIDOL [MI]

Common Name

English

Fenyramidol [WHO-DD]

Common Name

English

BENZENEMETHANOL, .ALPHA.-((2-PYRIDINYLAMINO)METHYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696