EPOLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H13NO
Molecular Weight	115.1735
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCN1CCCC1

InChI

InChIKey=XBRDBODLCHKXHI-UHFFFAOYSA-N

InChI=1S/C6H13NO/c8-6-5-7-3-1-2-4-7/h8H,1-6H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8980926 | https://www.flectorpatch.com/about-flector-patch

Epolamine (N-(2-hydroxyethyl)pyrrolidine) is a strong base used to salify organic acids of pharmaceutical interest in order to improve their solubility in water. Diclofenac epolamine (Flector) is an example of the epolamine salt of a drug.

Approval Year

PubMed

Title	Date	PubMed
Comparison of the physicochemical properties of the N-(2-hydroxyethyl) pyrrolidine, diethylamine and sodium salt forms of diclofenac.	2001 Jul 17	11427358
Diclofenac pyrrolidine versus Ketoprofen for the relief of pain from episiotomy: a randomized controlled trial.	2005 Oct	16167910
Ex vivo study of transdermal permeation of four diclofenac salts from different vehicles.	2007 Apr	17286288
Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries.	2008 Nov	18937623
Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine.	2008 Oct	18814824
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.	2009 Aug 13	19618939
In vitro cytotoxicity of benzopyranone derivatives with basic side chain against human lung cell lines.	2010 Nov	21115914
Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.	2010 Nov 10	21197326
Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury.	2010 Oct	20666849

Patents

Name

Type

Language

EPOLAMINE

Official Name

English

epolamine [INN]

Common Name

English

N-(2-HYDROXYETHYL)PYRROLIDINE

Systematic Name

English

NSC-26883

Code

English

Code System Code Type Description

EPA CompTox

DTXSID70183733