Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H32NO.Cl |
| Molecular Weight | 337.927 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].C[N+]3(CCC(O)(C1CCCCC1)C2=CC=CC=C2)CCCC3
InChI
InChIKey=PISKUTGWQHZKIK-UHFFFAOYSA-M
InChI=1S/C20H32NO.ClH/c1-21(15-8-9-16-21)17-14-20(22,18-10-4-2-5-11-18)19-12-6-3-7-13-19;/h2,4-5,10-11,19,22H,3,6-9,12-17H2,1H3;1H/q+1;/p-1
Tricyclamol is a quaternary ammonium compound, which is a crystalline odorless substance, readily soluble in water. It may be given by mouth or by subcutaneous injection. Tricyclamol was used for its spasmolytic action on smooth muscle. In animals it inhibits the spasmogenic effects of acetylcholine (ACh), carbachol, pilocarpine and barium chloride. In relaxing ACh-induced spasm of isolated rabbit ileum the activities of the dextro and laevo isomers of tricyclamol were approximately 0.006 and 2 times that of atropine sulphate respectively. Further, in inhibiting the stretch reflex of isolated guinea-pig ileum the laevo isomer was much more active than the dextro and about twice as potent as the racemate. Tricyclamol blocks the superior cervical ganglion. Tricyclamol chloride has a marked effect in reducing the motility of the stomach and duodenum, and to a far greater extent than the results produced by hyoscyamine. This action may be of value in controlling the pain of peptic ulceration, since it is likely that the pain, at least in part, is due to spasm.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism. | 1966 Jun |
|
| Drug-induced extrapyramidal symptoms: their incidence and treatment. | 1967 Jan |
|
| Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders. | 1970 Dec |
|
| Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders. | 1970 Dec |
|
| Central role of solar information flow in pregenetic evolution. | 1971 Jun |
|
| Parenteral long-acting phenothiazines. | 1972 Mar 25 |
|
| Letter: Delayed drug-induced dystonias. | 1973 Oct 20 |
|
| Abnormal involuntary movements induced by anticholinergic therapy. | 1974 |
|
| A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism. | 1977 Jun |
|
| Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule. | 1978 Oct 7 |
|
| Sleep disturbance associated with fluphenazine HCl: a case report. | 1979 Jul |
|
| Ethopropazine and benztropine in neuroleptic-induced parkinsonism. | 1979 Mar |
|
| Fluphenazine enanthate and fluphenazine decanoate in the treatment of schizophrenic outpatients: extrapyramidal symptoms and therapeutic effect. | 1982 Mar |
|
| Toxic neurological reaction to lithium/thioridazine. | 1983 Apr 2 |
|
| Neuroleptic malignant syndrome. | 1983 Jun 18 |
|
| Effects of mianserin in neuroleptic-induced parkinsonism. | 1986 |
|
| Rapid cycling following antidepressant in an adolescent. | 1990 May 15 |
|
| Antipsychotic drug-induced dysphoria. | 1996 Oct |
|
| Bilateral ulnar nerve paralysis: an unreported complication of drug-induced extrapyramidal rigidity. | 1997 Jun |
|
| Anti-nicotinic properties of anticholinergic antiparkinson drugs. | 1998 Nov |
|
| An extrapyramidal reaction to ondansetron. | 1998 Oct |
|
| Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. | 2002 Jan |
|
| Low dose quetiapine induced galactorrhoea: a case report. | 2007 Jul 24 |
|
| An overview of the clinical use of ondansetron in preschool age children. | 2007 Jun |
|
| Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study. | 2007 Jun |
|
| Newer antipsychotics and the rabbit syndrome. | 2007 Jun 11 |
|
| Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques. | 2007 Nov-Dec |
|
| Clozapine and co-prescribed psychotropics: a short report. | 2008 Apr 25 |
|
| Stuttering priapism--a review of the therapeutic options. | 2008 Aug |
|
| Anticonvulsant efficacy of drugs with cholinergic and/or glutamatergic antagonism microinfused into area tempestas of rats exposed to soman. | 2008 Feb |
|
| The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents. | 2008 Jun |
|
| Amisulpride plus valproate vs haloperidol plus valproate in the treatment of acute mania of bipolar I patients: a multicenter, open-label, randomized, comparative trial. | 2008 Jun |
|
| Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. | 2008 Jun |
|
| Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors. | 2008 Oct |
|
| Role of the central cholinergic system in the therapeutics of schizophrenia. | 2008 Sep |
|
| Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II. | 2009 Dec |
|
| Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. | 2009 Jul-Aug |
|
| Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. | 2009 Jun 3 |
|
| Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. | 2009 Mar |
|
| Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. | 2009 Nov |
|
| Acute dystonic reactions in a lady presenting with repetitive involuntary muscle twitching: a case report. | 2009 Nov 9 |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
| Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment. | 2010 Dec |
|
| Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. | 2010 Jan |
|
| The use of organotypic hippocampal slice cultures to evaluate protection by non-competitive NMDA receptor antagonists against excitotoxicity. | 2010 Mar |
|
| Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway. | 2010 Mar |
|
| Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents. | 2010 May |
|
| Structured relaxation in the treatment of akathisia: case series. | 2010 May 25 |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
|
| Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. | 2013 Dec 15 |
Patents
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C29701
Created by
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DTXSID10959111
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QYH21J350Z
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100000077720
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72169
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CHEMBL2110635
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3818-88-0
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SUB11279MIG
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C152739
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2736
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458
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223-311-5
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ACTIVE MOIETY
SUBSTANCE RECORD
