Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H27N3O4.ClH |
| Molecular Weight | 445.939 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC(=N)NC[C@H]1CC[C@@H](CC1)C(=O)OC2=C(C=CC=C2)C(=O)OCC3=CC=CC=C3
InChI
InChIKey=ZNYYFCHDQJQKOK-AELULUIVSA-N
InChI=1S/C23H27N3O4.ClH/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17;/h1-9,16,18H,10-15H2,(H4,24,25,26);1H/t16-,18-;
DescriptionCurator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/27446246
Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/27446246
Benexate is an active ingredient of benexate.CD or benexate hydrochloride betadex, a beta-cyclodextrin complex. Benexate was approved for the treatment of Gastric Ulcer in Japan. The terapeuthic effect of benexate is associated with promotion of prostaglandin synthesis, inhibition of acid secretion and increase in mucosal blood flow.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Syntheses and inhibitory effects on gastric lesions of trans-guanidinomethylcyclohexane carboxylic acid arylamides. | 1993 Mar |
|
| In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori. | 1996 May |
|
| Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory site in rats. | 1996 Oct |
|
| Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers. | 2016 Aug |
Patents
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m2310
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100000085015
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SUB00700MIG
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78718-25-9
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DTXSID80999968
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m2310
Created by
admin on Fri Dec 15 17:43:44 GMT 2023 , Edited by admin on Fri Dec 15 17:43:44 GMT 2023
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PRIMARY | Merck Index |
ACTIVE MOIETY
SUBSTANCE RECORD
