DIOLAMINE GLUCURONATE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H10O7.C4H11NO2
Molecular Weight	299.275
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCNCCO.O[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O

InChI

InChIKey=XQUKNPFXQIBKCF-JSCKKFHOSA-N

InChI=1S/C6H10O7.C4H11NO2/c7-1-2(8)3(9)4(10)5(11)6(12)13;6-3-1-5-2-4-7/h1-5,8-11H,(H,12,13);5-7H,1-4H2/t2-,3+,4-,5-;/m0./s1

HIDE SMILES / InChI

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/D-Glucuronic-Acid | https://www.ncbi.nlm.nih.gov/pubmed/7113260 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641160/

Glucuronic acid is a sugar acid that was first identified in urine. It is an intermediate metabolite of the uronic acid pathway. Moreover, glucuronic acid is involved in detoxification of certain drugs and toxins by conjugating with them and forming glucuronides. Glucuronic acid has been found to cause an increase in TLR4-dependent reporter protein expression in a cell line transfected with TLR4 and associated co-signaling molecules, and can cause TLR4-dependent pain in humans.

Approval Year

PubMed

Title	Date	PubMed
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.	2001	11170313
Probenecid-associated alterations in valproate glucuronide hepatobiliary disposition: mechanistic assessment using mathematical modeling.	2001 Apr	11259538
Cryopreservation of rat precision-cut liver slices by ultrarapid freezing: influence on phase I and II metabolism and on cell viability upon incubation for 24 hours.	2001 Apr 13	11350010
The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement.	2001 Apr 17	11296221
Rapid and simultaneous determination of mycophenolic acid and its glucuronide conjugate in human plasma by ion-pair reversed-phase high-performance liquid chromatography using isocratic elution.	2001 Apr 5	11334346
Identification of the major metabolites of prochloraz in rainbow trout by liquid chromatography and tandem mass spectrometry.	2001 Aug	11513673
Bisphenol a glucuronide, a major metabolite in rat bile after liver perfusion.	2001 Aug	11454725
Metabolic fate of 2,4-dichloroaniline, prochloraz and nonylphenol diethoxylate in rainbow trout: a comparative in vivo/in vitro approach.	2001 Aug	11408077
Intestinal absorption of rutin in free and conjugated forms.	2001 Aug 1	11434911
An electro-active system of immuno-assay (EASI assay) utilising self assembled monolayer modified electrodes.	2001 Dec	11679266
Mass spectrometry of steroid glucuronide conjugates. I. Electron impact fragmentation of 5alpha-/5beta-androstan-3alpha-ol-17-one glucuronides, 5alpha-estran-3alpha-ol-17-one glucuronide and deuterium-labelled analogues.	2001 Feb	11288198
Pharmacokinetic, pharmacodynamic, and outcome investigations as the basis for mycophenolic acid therapeutic drug monitoring in renal and heart transplant patients.	2001 Feb	11239510
Metabolism and disposition of alpha-methylstyrene in rats.	2001 Feb	11159807
Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney.	2001 Feb	11159800
Bioconcentration and distribution of 4-tert-octylphenol residues in tissues of the rainbow trout (Oncorhynchus mykiss).	2001 Feb	11125704
The ABC-like vacuolar transporter for rye mesophyll flavone glucuronides is not species-specific.	2001 Jan	11219807
LC-1H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems.	2001 Jan	11199227
Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man.	2001 Jul	11480539
Isolation of an unknown metabolite of the non-steroidal anti-inflammatory drug etodolac and its identification as 5-hydroxy etodolac.	2001 Jul	11377082
Determination of the chemical structure of the capsular polysaccharide of strain B33, a fast-growing soya bean-nodulating bacterium isolated from an arid region of China.	2001 Jul 15	11439101
Functional expression of multidrug resistance protein 1 in Pichia pastoris.	2001 Jul 27	11444977
Importance of vacutainer selection in forensic toxicological analysis of drugs of abuse.	2001 Jul-Aug	11499888
Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver.	2001 Jun	11513245
GC-FID as a primary method for establishing the purity of organic CRMs used for drugs in sport analysis.	2001 Jun	11451235
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.	2001 Jun	11377097
In vivo and in vitro percutaneous absorption of [(14)C]di-N-butylphthalate in rat.	2001 Jun	11353753
Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide.	2001 Jun 5	11419733
Separation and characterization of gall bladder bile metabolites from speckled trout, Salvelinus fontinalis, exposed to individual polycyclic aromatic compounds.	2001 Mar	11349864
Synthesis of the beta-D-glucuronides of 2,3-, 3,4-, and 2,6-dichlorophenol.	2001 Mar	11315335
Tissue distribution, excretion, and metabolism of 1,2,7,8-tetrachlorodibenzo-p-dioxin in the rat.	2001 Mar	11272921
Application of LC-MS analysis to the characterisation of the in vitro and in vivo metabolite profiles of RGH-1756 in the rat.	2001 Mar	11248481
Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.	2001 Mar	11181489
Determination of salicylate, gentisic acid and salicyluric acid in human urine by capillary electrophoresis with laser-induced fluorescence detection.	2001 Mar 5	11254191
Determination of 3-trifluoromethyl-4-nitrophenol and 3-trifluoromethyl-4-nitrophenol glucuronide in edible fillet tissue of rainbow trout and channel catfish by solid-phase extraction and liquid chromatography.	2001 Mar-Apr	11324603
Adrenal steroids in human prostatic cancer cell lines.	2001 Mar-Apr	11297065
Biotransformation of MTBE, ETBE, and TAME after inhalation or ingestion in rats and humans.	2001 May	11504147
Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.	2001 May	11302935
Applications of liquid chromatography-tandem mass spectrometry in drug and biomedical analyses.	2001 Nov	11694253
Lamotrigine plasma levels reduced by oral contraceptives.	2001 Nov	11673029
Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate.	2001 Oct	11557524
Fluorogenic assay for beta-glucuronidase using microchip-based capillary electrophoresis.	2001 Oct 5	11589456
Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.	2001 Sep	11683238
Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.	2001 Sep	11604552
Mass spectrometry of steroid glucuronide conjugates. II-Electron impact fragmentation of 3-keto-4-en- and 3-keto-5alpha-steroid-17-O-beta glucuronides and 5alpha-steroid-3alpha,17beta-diol 3- and 17-glucuronides.	2001 Sep	11599078

Patents

Name

Type

Language

DIOLAMINE GLUCURONATE

Common Name

English

D-GLUCURONIC ACID, COMPOUND WITH 2,2'-IMINOBIS(ETHANOL) (1:1)

Common Name

English

DIETHANOLAMINE GLUCURONATE

Common Name

English

ETHANOL, 2,2'-IMINOBIS-, D-GLUCURONATE (SALT)

Common Name

English

Diethanolamine glucuronate [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

94108-04-0