Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H27N5O7S.3H2O |
| Molecular Weight | 547.579 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)[C@H](N)CC(=O)NC)C3=CC=C(O)C=C3)C(O)=O
InChI
InChIKey=TXQFNMPGORBMME-GPIZLFNGSA-N
InChI=1S/C21H27N5O7S.3H2O/c1-21(2)15(20(32)33)26-18(31)14(19(26)34-21)25-17(30)13(9-4-6-10(27)7-5-9)24-16(29)11(22)8-12(28)23-3;;;/h4-7,11,13-15,19,27H,8,22H2,1-3H3,(H,23,28)(H,24,29)(H,25,30)(H,32,33);3*1H2/t11-,13-,14-,15+,19-;;;/m1.../s1
DescriptionSources: DOI: 10.1016/S0065-7743(08)60861-1Curator's Comment: description was created based on several sources, including:
http://www.drugfuture.com/chemdata/ASPOXICILLIN.html
http://www.120ty.net/bencandy.php?fid=232&id=36758
http://www.229877.com/article/2012/1209/31983.html
Sources: DOI: 10.1016/S0065-7743(08)60861-1
Curator's Comment: description was created based on several sources, including:
http://www.drugfuture.com/chemdata/ASPOXICILLIN.html
http://www.120ty.net/bencandy.php?fid=232&id=36758
http://www.229877.com/article/2012/1209/31983.html
Aspoxicillin is an injectable, amino acid-type penicillin highly active against Gram-positive ad Gram-negative bacteria, including the beta-lactamase producing Bacillus fragilis. It is reportedly effective in the treatment of peritonitis, pneumonia and bronchitis. Adverse reactions are: rash, urticaria, skin itching, vomiting, abdominal pain.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2354204 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
Sources: http://www.229877.com/article/2012/1209/31983.html DOI: 10.1016/S0065-7743(08)60861-1 |
Curative | Doyle Approved UseIt is reportedly effective in the treatment of peritonitis |
||
Sources: DOI: 10.1016/S0065-7743(08)60861-1 http://www.229877.com/article/2012/1209/31983.html |
Curative | Doyle Approved UseIt is used for treatment of pneumonia |
||
Sources: DOI: 10.1016/S0065-7743(08)60861-1 http://www.229877.com/article/2012/1209/31983.html |
Curative | Doyle Approved UseIt is used for treatment of chronic and acute bronchitis |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Aspoxicillin versus piperacillin in severe abdominal infections--a comparative phase III study. | 1994 Nov |
|
| Morphological changes and lysis induced by beta-lactams associated with the characteristic profiles of affinities of penicillin-binding proteins in actinobacillus pleuropneumoniae. | 2000 Jun |
|
| Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae. | 2002 Jan |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: For children: 40-80 mg/kg; in severe cases – 60 mg/kg, 2-4 injections per day
1-2 g twice a day, in severe infections – 6-8 g per day
Route of Administration:
Intravenous
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12905357
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DTXSID80151908
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117774-38-6
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QL05X0PL6T
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ACTIVE MOIETY
SUBSTANCE RECORD
