Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H30N2O5 |
| Molecular Weight | 402.484 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OC
InChI
InChIKey=DBAQBRAQKYAQEO-GBBGEASQSA-N
InChI=1S/C22H30N2O5/c1-14(20(25)24-18-10-6-9-16(18)13-19(24)21(26)27)23-17(22(28)29-2)12-11-15-7-4-3-5-8-15/h3-5,7-8,14,16-19,23H,6,9-13H2,1-2H3,(H,26,27)/t14-,16-,17-,18-,19-/m0/s1
Ramipril methyl ester is the proline-containing impurity of ramipril, labelled as ramipril Impurity A. It is one of the four qualified impurities. Impurity A is the manufacture process impurity. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules. | 2000 Sep |
|
| Development of a capillary electrophoresis method for the assay of ramipril and its impurities: an issue of cis-trans isomerization. | 2011 May 6 |
Patents
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QKQ7F3PK42
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1598314
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11611080
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108313-11-7
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admin on Sat Dec 16 08:18:00 GMT 2023 , Edited by admin on Sat Dec 16 08:18:00 GMT 2023
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SUBSTANCE RECORD
